| Texto completo | |
| Autor(es): |
Razzokov, Jamoliddin
[1]
;
Yusupov, Maksudbek
[1]
;
Cordeiro, Rodrigo M.
[2]
;
Bogaerts, Annemie
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Antwerp, Dept Chem, Res Grp PLASMANT, Univ Pl 1, B-2610 Antwerp - Belgium
[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF PHYSICS D-APPLIED PHYSICS; v. 51, n. 36 SEP 12 2018. |
| Citações Web of Science: | 5 |
| Resumo | |
Cold atmospheric plasmas (CAPs) have attracted significant interest for then potential benefits in medical applications, including cancer therapy. The therapeutic effects of CAPs are related to reactive oxygen and nitrogen species (ROS and RNS) present in the plasma. The impact of ROS has been extensively studied, but the role of RNS in CAP-treatment remains poorly understood at the molecular level. Here, we investigate the permeation of RNS and ROS across native and oxidized phospholipid bilayers (PLBs) by means of computer simulations. The results reveal significantly lower free energy barriers for RNS (i.e. NO, NO2, N2O4) and O-3 compared to hydrophilic ROS, such as OH, HO; and H2O2. This suggests that the investigated RNS and O-3 can permeate more easily through both native and oxidized PLBs in comparison to hydrophilic ROS, indicating their potentially important role in plasma medicine. (AU) | |
| Processo FAPESP: | 12/50680-5 - Fotossensibilização nas ciências da vida |
| Beneficiário: | Mauricio da Silva Baptista |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |