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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Atomic scale understanding of the permeation of plasma species across native and oxidized membranes

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Razzokov, Jamoliddin [1] ; Yusupov, Maksudbek [1] ; Cordeiro, Rodrigo M. [2] ; Bogaerts, Annemie [1]
Total Authors: 4
[1] Univ Antwerp, Dept Chem, Res Grp PLASMANT, Univ Pl 1, B-2610 Antwerp - Belgium
[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF PHYSICS D-APPLIED PHYSICS; v. 51, n. 36 SEP 12 2018.
Web of Science Citations: 4

Cold atmospheric plasmas (CAPs) have attracted significant interest for then potential benefits in medical applications, including cancer therapy. The therapeutic effects of CAPs are related to reactive oxygen and nitrogen species (ROS and RNS) present in the plasma. The impact of ROS has been extensively studied, but the role of RNS in CAP-treatment remains poorly understood at the molecular level. Here, we investigate the permeation of RNS and ROS across native and oxidized phospholipid bilayers (PLBs) by means of computer simulations. The results reveal significantly lower free energy barriers for RNS (i.e. NO, NO2, N2O4) and O-3 compared to hydrophilic ROS, such as OH, HO; and H2O2. This suggests that the investigated RNS and O-3 can permeate more easily through both native and oxidized PLBs in comparison to hydrophilic ROS, indicating their potentially important role in plasma medicine. (AU)

FAPESP's process: 12/50680-5 - Photosensitization in life sciences
Grantee:Mauricio da Silva Baptista
Support type: Research Projects - Thematic Grants