The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

Autor(es)

Marchese, Leticia ^[1] ; Nascimento, Janaina de Freitas ^[1] ; Damasceno, Flavia Silva ^[1] ; Bringaud, Frederic ^[2] ; Michels, Paul A. M. ^{[3, 4]} ; Silber, Ariel Mariano ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Lab Biochem Tryps LaBTryps, Av Lineu Prestes 1374, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Bordeaux, Lab Microbiol Fondamentale & Pathogen MFP, CNRS, UMR 5234, 146 Rue Leo Saignat, Batiment 3A, F-33076 Bordeaux - France

^[3] Univ Edinburgh, Ctr Immun Infect & Evolut, Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian - Scotland

^[4] Univ Edinburgh, Ashworth Labs, Sch Biol Sci, Ctr Translat & Chem Biol, Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian - Scotland

• Tipo de documento: Artigo de Revisão
• Fonte: PATHOGENS; v. 7, n. 2 JUN 2018.
• Citações Web of Science: 7

Resumo

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts. (AU)

• Processo FAPESP: 16/06034-2 - O papel biológico de aminoácidos e seus metabólitos derivados em Trypanosoma cruzi
• Beneficiário: Ariel Mariano Silber
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/16553-0 - O papel das isoformas mitocondrial e glicossomal da fumarato redutase na bioenergética de Trypanosoma cruzi
• Beneficiário: Ariel Mariano Silber
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional