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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

New Polyhydroxylated Steroidal Saponins from Solanum paniculatum L. Leaf Alcohol Tincture with Antibacterial Activity against Oral Pathogens

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Autor(es):
Valerino-Diaz, Alexander B. [1] ; Gamiotea-Turro, Daylin [1] ; Zanatta, Ana C. [1] ; Vilegas, Wagner [2] ; Gomes Martins, Carlos Henrique [3] ; Silva, Thayna de Souza [3] ; Rastrelli, Luca [4] ; dos Santos, Lourdes Campaner [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, UNESP, Inst Chem, Rua Prof Francisco Degni 55, BR-14800060 Araraquara, SP - Brazil
[2] Sao Paulo State Univ, UNESP, Inst Biosci, Praca Infante Dom Henrique S-N, BR-11330900 Sao Vicente, SP - Brazil
[3] UNIFRAN Univ Franca, Lab Res Appl Microbiol, Av Dr Armando Salles Oliveira 201, BR-14404600 Franca, SP - Brazil
[4] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo 2, I-84084 Salerno - Italy
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Agricultural and Food Chemistry; v. 66, n. 33, p. 8703-8713, AUG 22 2018.
Citações Web of Science: 2
Resumo

Solanum paniculatum L. is widely used in Brazilian folk medicine for the treatment of liver and gastrointestinal disorders as well as for culinary purposes and beverage production. Fractionation of hydroalcoholic {[}ethanol (EtOH) 70%] tincture from S. paniculatum leaves led to the isolation of six new spirostanic saponins which included 6-O-alpha-L-rhamnopyranosyl-(1{''}-> 3')-beta-D-quinovopyranosyl-(22S,23R,25S)-3 beta,6 alpha,23-trihydroxy-5 alpha-spirostane (1), 6-O-beta-D-xylopyranosyl-(1{''}-> 3')-beta-D-quinovopyranosyl-(22S,23R,25R)-3 beta,6 alpha,23-trihydroxy-5 alpha-spirostane (4), 3-O-alpha-L-rhamnopyranosyl-(1{''}-> 3')-beta-D-quinovopyranosyl-(22S,23S,25R)-3 beta,6 alpha,23-trihydroxy-5 alpha-spirostane (5), 3-O-beta-D-xylopyranosyl-(1{''}-> 3')-beta-D-quinovopyranosyl-(22S,23S,25R)-3 beta,6 alpha,23-trihydroxy-5 alpha-spirostane (6), 6-O-alpha-L-rhamnopyranosyl-(1{''}-> 3')-beta-D-quinovopyranosyl(22S,25S)-1 beta,3 beta,6 alpha-trihydroxy-5 alpha-spirostane (7), and 6-O-beta-D-xylopyranosyl-(1{''}-> 3')-beta-D-quinovopyranosyl-(22S,25S)-3 beta,4 beta,6 alpha-trihydroxy-5 alpha-spirostane (8) together with two known spirostanic saponins (2, 3). The structures of these compounds were determined by one-dimensional (1D) and two-dimensional (2D) NMR experiments in addition to high resolution electrospray ionization mass spectrometry (HRESIMS) analyses. The 70% alcohol tincture, used as phytomedicine, exhibited promising activities against oral pathogens, including, Steptococcus sanguinis, St. oralis, St. mutans, St. mitis, and Lactobacillus casei with minimal inhibitory concentration (MIC) values ranging from 6.25 to 50 mu g/mL. The saponin fraction, nonetheless, showed lower activity against all the strains tested (from 100 to >400 mu g/mL). (AU)

Processo FAPESP: 15/04899-3 - Estudo químico dos extratos produzidos por fungos endofíticos associados às partes aéreas de espécies de Eriocaulaceae e sua atividade antimicrobiana
Beneficiário:Lourdes Campaner dos Santos
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/52237-9 - Fitoterápicos padronizados como alvo para o tratamento de doenças crônicas
Beneficiário:Wagner Vilegas
Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Temático