Ascorbic acid co-administered with rosuvastatin reduces reproductive impairment in the male offspring from male rats exposed to the statin at pre-puberty

Autor(es)

Araujo Leite, Gabriel Adan ^{[1, 2]} ; Figueiredo, Thamiris Moreira ^[1] ; Guerra, Marina Trevizan ^[1] ; Borges, Cibele dos Santos ^[1] ; Fernandes, Fabio Henrique ^[3] ; Anselmo-Franci, Janete Aparecida ^[4] ; Kempinas, Wilma De Grava ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil

^[2] State Univ Campinas UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, Campinas, SP - Brazil

^[3] Sao Paulo State Univ Unesp, Med Sch, Dept Pathol, Botucatu, SP - Brazil

^[4] Univ Sao Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food and Chemical Toxicology; v. 118, p. 416-429, AUG 2018.
• Citações Web of Science: 2

Resumo

Obesity during childhood and adolescence is closely related to dysfunctions on lipid profile in children. Rosuvastatin is a statin that decreases serum total cholesterol. Ascorbic acid is an important antioxidant compound for male reproduction. Pre-pubertal male rats were distributed into six experimental groups that received saline solution 0.9% (vehicle), 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/ kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid by gavage from post-natal day (PND) 23 until PND53. Rats were maintained until adulthood and mated with nulliparous females to obtain the male offspring, whose animals were evaluated at adulthood in relation to reproductive parameters. This study is a follow up of a previous paper addressing potential effects on F0 generation only (Leite et al., 2017). Male offspring from rosuvastatin-exposed groups showed increased sperm DNA fragmentation, androgen depletion and impairment on the testicular and epididymal structure. Ascorbic acid coadministered to the fathers ameliorated the reproductive damage in the offspring. In summary, paternal exposure to rosuvastatin may affect the reproduction in the male offspring; however, paternal supplementation with ascorbic acid was able to reduce the reproductive impairment in the male offspring caused by statin treatment to the fathers. (AU)

• Processo FAPESP: 14/13659-3 - Exposição de ratos machos à rosuvastatina na presença ou ausência de vitamina C na pré-puberdade: efeitos imediatos e tardios sobre o sistema genital masculino
• Beneficiário: Thamiris Moreira Figueiredo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/22495-1 - Exposição de ratos machos à rosuvastatina na pré-puberdade, na ausência ou presença de vitamina C: efeitos imediatos e tardios sobre o sistema genital e a fertilidade das gerações F0 e F1
• Beneficiário: Gabriel Adan Araújo Leite
• Modalidade de apoio: Bolsas no Brasil - Doutorado