Differential gene expression to an LPS challenge in relation to exogenous corticosterone in the invasive cane toad (Rhinella marina)

Autor(es)

Gardner, Steven ^[1] ; Assis, Vania Regina ^[2] ; Zha, Honggang ^[3] ; Gomes, Fernando Ribeiro ^[2] ; Peatman, Eric ^[3] ; Mendonca, Mary T. ^[1]

Afiliação do(s) autor(es)

^[1] Auburn Univ, Dept Biol Sci, 331 Funchess Hall, 350 South Coll St, Auburn, AL 36849 - USA

^[2] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Rua Matao, Trav 14, 101, BR-05508900 Sao Paulo, SP - Brazil

^[3] Auburn Univ, Sch Fisheries Aquaculture & Aquat Sci, 377 CASIC Bldg, Auburn, AL 36849 - USA

• Tipo de documento: Artigo Científico
• Fonte: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY; v. 88, p. 114-123, NOV 2018.
• Citações Web of Science: 0

Resumo

The cane toad (Rhinella marina) is an invasive amphibian in several parts of the world. Much of the research performed on assessing the dispersal potential of invasive species has focused immunity. Invaders are predicted to rely less on pro-inflammatory immunity, allowing them to allocate energy to dispersal. Elevated stress may play a role in regulation of immune responses used by invasive species. RNA sequencing of spleen tissue from cane toads subjected to an acute LPS challenge revealed genes coding for cytokines involved in typical innate responses such as phagocytic cell recruitment, extravasation, inflammation, and lymphocyte differentiation were significantly upregulated, while toads receiving transdermal application of corticosterone in addition to an LPS injection showed downregulation of genes involved with cell mediated immunity. These results indicate hormonal changes associated with acute stress may alter investment into mounting cell-mediated or humoral responses while allowing for prolonged phagocytic innate responses in this invasive species. (AU)

• Processo FAPESP: 14/05806-6 - Efeitos do estresse agudo de restrição de movimentos, da aplicação transdérmica de corticosterona e do implante subcutâneo de testosterona na imunocompetência e nos níveis plasmáticos de corticosterona e testosterona no SAPO cururu (Rhinella marina)
• Beneficiário: Vania Regina de Assis
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 17/04802-5 - Efeitos do tratamento prolongado com corticosterona sobre o estresse e a resposta imune em sapos da cana (Rhinella marina)
• Beneficiário: Vania Regina de Assis
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado