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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Vaginal lipidomics of women with vulvovaginal candidiasis and cytolytic vaginosis: A non-targeted LC-MS pilot study

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Autor(es):
Sanches, Jose Marcos [1] ; Giraldo, Paulo Cesar [1] ; Amaral, Rose [1] ; Eberlin, Marcos Nogueira [2] ; Marques, Lygia Azevedo [2] ; Migliorini, Isabel [1] ; Nakahira, Marcel [2] ; Marinus Bieleveld, Michel Jan [3] ; Discacciati, Michelle Garcia [4]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Tocoginecol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Chem, Campinas, SP - Brazil
[3] Univ Sao Paulo, Polytech Sch, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Sch Pharmaceut Sci, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 13, n. 8 AUG 22 2018.
Citações Web of Science: 0
Resumo

Objective To characterize the lipid profile in vaginal discharge of women with vulvovaginal candidiasis, cytolytic vaginosis, or no vaginal infection or dysbiosis. Design Cross-sectional study. Setting Genital Infections Ambulatory, Department of Tocogynecology, University of Campinas, Campinas, Sao Paulo-Brazil. Sample Twenty-four women were included in this study: eight with vulvovaginal candidiasis, eight with cytolytic vaginosis and eight with no vaginal infections or dysbiosis (control group). Methods The lipid profile in vaginal discharge of the different study groups was determined by liquid chromatography-mass spectrometry and further analyzed with MetaboAnalyst 3.0 platform. Main outcome measures Vaginal lipids concentration and its correlation with vulvovaginal candidiasis and cytolytic vaginosis. Results PCA, PLS-DA and hierarchical clustering analyses indicated 38 potential lipid biomarkers for the different groups, correlating with oxidative stress, inflammation, apoptosis and integrity of the vaginal epithelial tissue. Among these, greater concentrations were found for Glycochenodeoxycholic acid-7-sulfate, O-adipoylcarnitine, 1-eicosyl-2-heptadecanoyl-glycero3- phosphoserine, undecanoic acid, formyl dodecanoate and lipoic acid in the vulvovaginal candidiasis group; N-(tetradecanoyl)-sphinganine, DL-PPMP, 1-oleoyl-cyclic phosphatidic, palmitic acid and 5-aminopentanoic acid in the cytolytic vaginosis group; and 1-nonadecanoyl-glycero-3-phosphate, eicosadienoic acid, 1-stearoyl-cyclic-phosphatidic acid, 1-(9Z, 12Z-heptadecadienoyl)-glycero-3-phosphate, formyl 9Z-tetradecenoate and 7Z, 10Z-hexadecadienoic acid in the control group. Conclusions Lipids related to oxidative stress and apoptosis were found in higher concentrations in women with vulvovaginal candidiasis and cytolytic vaginosis, while lipids related to epithelial tissue integrity were more pronounced in the control group. Furthermore, in women with cytolytic vaginosis, we observed higher concentrations of lipids related to bacterial overgrowth. (AU)

Processo FAPESP: 16/18850-9 - Análise lipidômica do conteúdo vaginal de mulheres com candidíase e vaginose citolítica
Beneficiário:José Marcos Sanches Junior
Modalidade de apoio: Bolsas no Brasil - Mestrado