Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies

Autor(es):Mostrar menos -

Gielen, Marij ^[1] ; Hageman, Geja J. ^[2] ; Antoniou, Evangelia E. ^[3] ; Nordfjall, Katarina ^[4] ; Mangino, Massimo ^{[5, 6]} ; Balasubramanyam, Muthuswamy ^[7] ; de Meyer, Tim ^[8] ; Hendricks, Audrey E. ^{[9, 10]} ; Giltay, Erik J. ^[11] ; Hunt, Steven C. ^[12] ; Nettleton, Jennifer A. ^[13] ; Salpea, Klelia D. ^[14] ; Diaz, Vanessa A. ^[15] ; Farzaneh-Far, Ramin ^[16] ; Atzmon, Gil ^{[17, 18]} ; Harris, Sarah E. ^{[19, 20, 21, 22]} ; Hou, Lifang ^{[23, 24]} ; Gilley, David ^[25] ; Hovatta, Iiris ^{[26, 27]} ; Kark, Jeremy D. ^[28] ; Nassar, Hisham ^[29] ; Kurz, David J. ^[30] ; Mather, Karen A. ^[31] ; Willeit, Peter ^{[32, 33]} ; Zheng, Yun-Ling ^[34] ; Pavanello, Sofia ^[35] ; Demerath, Ellen W. ^[36] ; Rode, Line ^[37] ; Bunout, Daniel ^[38] ; Steptoe, Andrew ^[39] ; Boardman, Lisa ^[40] ; Marti, Amelia ^{[41, 42, 43]} ; Needham, Belinda ^[44] ; Zheng, Wei ^[45] ; Ramsey-Goldman, Rosalind ^[46] ; Pellatt, Andrew J. ^[47] ; Kaprio, Jaakko ^{[48, 49]} ; Hofmann, Jonathan N. ^[50] ; Gieger, Christian ^{[51, 52]} ; Paolisso, Giuseppe ^[53] ; Hjelmborg, Jacob B. H. ^[54] ; Mirabello, Lisa ^[53] ; Seeman, Teresa ^[55] ; Wong, Jason ^[56] ; van der Harst, Pim ^[57] ; Broer, Linda ^[58] ; Kronenberg, Florian ^[59] ; Kollerits, Barbara ^[59] ; Strandberg, Timo ^{[60, 61, 62]} ; Eisenberg, Dan T. A. ^{[63, 64]} ; Duggan, Catherine ^[65] ; Verhoeven, Josine E. ^[66] ; Schaakxs, Roxanne ^[66] ; Zannolli, Raffaela ^[67] ; dos Reis, Rosana M. R. ^[68] ; Charchar, Fadi J. ^{[69, 70]} ; Tomaszewski, Maciej ^{[71, 72]} ; Mons, Ute ^{[73, 74]} ; Demuth, Ilja ^{[75, 76]} ; Molli, Andrea Elena Iglesias ^[77] ; Cheng, Guo ^[78] ; Krasnienkov, Dmytro ^[79] ; D'Antono, Bianca ^{[80, 81]} ; Kasielski, Marek ^[82] ; McDonnell, Barry J. ^[83] ; Ebstein, Richard Paul ^[84] ; Sundquist, Kristina ^[85] ; Pare, Guillaume ^{[86, 87]} ; Chong, Michael ^{[86, 87]} ; Zeegers, Maurice P. ^{[1, 88]} ; Group, TELOMAAS

Afiliação do(s) autor(es):Mostrar menos -

^[1] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Dept Complex Genet, Maastricht - Netherlands

^[2] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Dept Toxicol, Maastricht - Netherlands

^[3] Maastricht Univ, Fac Psychol & Neurosci, Dept Clin Psychol Sci, Maastricht - Netherlands

^[4] Ostersund Hosp, Dept Med, Ostersund - Sweden

^[5] Kings Coll London, Twin Res & Genet Epidemiol, London - England

^[6] Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London - England

^[7] Madras Diabet Res Fdn, Cell & Mol Biol, Madras, Tamil Nadu - India

^[8] Univ Ghent, Dept Math Modeling Stat & Bioinformat, Ghent - Belgium

^[9] NHLBI, Populat Sci Branch, NIH, Framingham Heart Study, Framingham, MA - USA

^[10] Univ Colorado Denver, Dept Math & Stat Sci, Denver, CO - USA

^[11] Leiden Univ, Med Ctr, Dept Psychiat, Leiden - Netherlands

^[12] Univ Utah, Dept Med, Cardiovasc Genet Div, Salt Lake City, UT 84112 - USA

^[13] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Houston, TX 77030 - USA

^[14] BSRC Alexander Fleming, Dept Mol Biol & Genet, Athens - Greece

^[15] Med Univ South Carolina, Dept Family Med, Charleston, SC 29425 - USA

^[16] San Francisco Gen Hosp, Div Cardiol, San Francisco, CA 94110 - USA

^[17] Albert Einstein Coll Med, Dept Med & Genet, Bronx, NY 10467 - USA

^[18] Univ Haifa, Fac Nat Sci, Dept Biol, Haifa - Israel

^[19] Univ Edinburgh, Ctr Cognit Aging & Cognit Epidemiol, Edinburgh, Midlothian - Scotland

^[20] Univ Edinburgh, Med Genet Sect, Edinburgh, Midlothian - Scotland

^[21] Univ Edinburgh, Ctr Genom & Expt Med, Edinburgh, Midlothian - Scotland

^[22] Univ Edinburgh, MRC, Inst Genet & Mol Med, Edinburgh, Midlothian - Scotland

^[23] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 - USA

^[24] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 - USA

^[25] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 - USA

^[26] Univ Helsinki, Dept Biosci, Helsinki - Finland

^[27] Natl Inst Hlth & Welf, Dept Hlth, Helsinki - Finland

^[28] Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth & Community Med, Epidemiol Unit, Jerusalem - Israel

^[29] Hadassah Univ Med Ctr, Dept Cardiol, Jerusalem - Israel

^[30] Triemli Hosp, Dept Cardiol, Zurich - Switzerland

^[31] UNSW Australia, Ctr Hlth Brain Ageing, Psychiat, Sydney, NSW - Australia

^[32] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge - England

^[33] Med Univ Innsbruck, Dept Neurol, Innsbruck - Austria

^[34] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 - USA

^[35] Univ Padua, Unit Occupat Med, Dept Cardiac Thorac & Vasc Sci, Padua - Italy

^[36] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN - USA

^[37] Herlev & Gentofte Hosp, Copenhagen Univ Hosp, Dept Clin Biochem, Copenhagen Gen Populat Study, Copenhagen - Denmark

^[38] Univ Chile, Inst Nutr & Food Technol, Santiago - Chile

^[39] UCL, Dept Epidemiol & Publ Hlth, London - England

^[40] Mayo Clin, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Rochester, MN - USA

^[41] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona - Spain

^[42] Inst Invest Sanitaria Navarra, Pamplona - Spain

^[43] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid - Spain

^[44] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 - USA

^[45] Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Vanderbilt, Nashville, TN - USA

^[46] Northwestern Univ, Feinberg Sch Med, Div Rheumatol, Chicago, IL 60611 - USA

^[47] Univ Utah, Dept Med, Salt Lake City, UT 84112 - USA

^[48] Univ Helsinki, Dept Publ Hlth, Helsinki - Finland

^[49] Univ Helsinki, Inst Mol Med, Helsinki - Finland

^[50] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 - USA

^[51] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg - Germany

^[52] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg - Germany

^[53] Univ Naples 2, Dept Med Surg Neurol Metab & Geriatr Sci, Naples - Italy

^[54] Univ Southern Denmark, Inst Publ Hlth, Dept Epidemiol Biostat & Biodemog, Odense C - Denmark

^[55] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 - USA

^[56] Stanford Univ, Sch Med, Stanford, CA 94305 - USA

^[57] Univ Med Ctr Groningen, Dept Cardiol, Groningen - Netherlands

^[58] Erasmus MC, Dept Internal Med, Rotterdam - Netherlands

^[59] Med Univ Innsbruck, Dept Med Genet Mol & Clin Pharmacol, Div Genet Epidemiol, Innsbruck - Austria

^[60] Univ Helsinki, Helsinki - Finland

^[61] Univ Helsinki, Cent Hosp, Helsinki - Finland

^[62] Univ Oulu, Ctr Life Course Epidemiol, Oulu - Finland

^[63] Univ Washington, Dept Anthropol, Seattle, WA 98195 - USA

^[64] Univ Washington, Ctr Studies Demog & Ecol, Seattle, WA 98195 - USA

^[65] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 - USA

^[66] Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam - Netherlands

^[67] Univ Siena, Senese, Policlin Le Scotte, Pediat Unit, Azienda Osped Univ, Siena - Italy

^[68] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Gynecol & Obstet, Ribeirao Preto, SP - Brazil

^[69] Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics - England

^[70] Univ Melbourne, Dept Physiol, Federat Univ Australia, Sch Sci & Technol, Melbourne, Vic - Australia

^[71] Univ Manchester, Div Cardiovasc Sci, Fac Med Biol & Hlth, Manchester, Lancs - England

^[72] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Div Med, Manchester, Lancs - England

^[73] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg - Germany

^[74] German Canc Res Ctr, Canc Prevent Unit, Heidelberg - Germany

^[75] Charite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Berlin - Germany

^[76] Berlin Inst Hlth, Lipid Clin, Interdisciplinary Metab Ctr, Berlin - Germany

^[77] Univ Buenos Aires, CONICET, Inst Inmunol Genet & Metab INIGEM, Lab Diabet & Metab, Buenos Aires, DF - Argentina

^[78] Sichuan Univ, West China Sch Publ Hlth, Dept Nutr Food Safety & Toxicol, Chengdu, Sichuan - Peoples R China

^[79] NAMS Ukraine, DF Chebotarev State Inst Gerontol, Dept Epigenet, Kiev - Ukraine

^[80] Univ Montreal, Montreal Heart Inst, Res Ctr, Montreal, PQ - Canada

^[81] Univ Montreal, Dept Psychol, Montreal, PQ - Canada

^[82] Med Univ Lodz, Bases Clin Med Teaching Ctr, Lodz - Poland

^[83] Cardiff Metropolitan Univ, Cardiff Sch Sport & Hlth Sci, Cardiff, S Glam - Wales

^[84] Natl Univ Singapore, Dept Psychol, Singapore - Singapore

^[85] Lund Univ, Ctr Primary Hlth Care Res, Reg Skane, Lund - Sweden

^[86] McMaster Univ, Hamilton, ON - Canada

^[87] Populat Hlth Res Inst, Hamilton, ON - Canada

^[88] Maastricht Univ, CAPHRI Sch Publ Hlth & Primary Care, Maastricht - Netherlands

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF CLINICAL NUTRITION; v. 108, n. 3, p. 453-475, SEP 2018.
• Citações Web of Science: 10

Resumo

Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Study-specific age-and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute {[}base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories ({''}young{''}: 18-60 y; ``middle{''}: 61-75 y; and ``old{''}: > 75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 x 10(-3) unit T/S ratio (0.16% decrease; 95% CI: -2.14 x 10(-3), -1.01 x 10(-3)) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 x 10(-3) unit T/S ratio (0.26% decrease; 95% CI: -3.92 x 10(-3), -1.25 x 10(-3)). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL are warranted. (AU)

• Processo FAPESP: 10/08800-8 - Repercussões do exercício físico resistido periodizado em mulheres portadoras de anovulação hiperandrogênica
• Beneficiário: Rosana Maria dos Reis
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/11566-2 - Polimorfismo cag do receptor de andrógenos e comprimento do telômero em pacientes com falência ovariana prematura
• Beneficiário: Rosana Maria dos Reis
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/11069-9 - Polimorfismo cag do receptor de andrógenos e comprimento do telômero em pacientes com falência ovariana prematura
• Beneficiário: Cristiana Libardi Miranda Furtado
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado