Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors

Autor(es):Mostrar menos -

Bidinotto, Lucas Tadeu ^{[1, 2]} ; Veo, Carlos A. R. ^[1] ; Loaiza, Edgar Aleman ^[1] ; Ribeiro, Guilherme G. ^[1] ; Lorenzi, Adriana T. ^[1] ; Reis Rosa, Luciana Albina ^[3] ; de Oliveira, Cristina Mendes ^[3] ; Levi, Jose Eduardo ^[3] ; Scapulatempo-Neto, Cristovam ^{[4, 1]} ; Longatto-Filho, Adhemar ^{[1, 5, 6]} ; Reis, Rui Manuel ^{[1, 5, 6]}

Afiliação do(s) autor(es)

^[1] Barretos Canc Hosp, Mol Oncol Res Ctr, 1331 Antenor Duarte Villela, BR-14784400 Barretos, SP - Brazil

^[2] Dr Paulo Prata FACISB, Barretos Sch Hlth Sci, Human & Expt Biol Dept, BR-14785002 Barretos, SP - Brazil

^[3] Univ Sao Paulo, Inst Trop Med, Lab Virol, BR-05403000 Sao Paulo, SP - Brazil

^[4] Barretos Canc Hosp, Dept Pathol, BR-14784400 Barretos, SP - Brazil

^[5] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst, P-4704553 Braga - Portugal

^[6] Portugal Govt Associate Lab, Res Grp, Biomat Biodegradables & Biomimet 3Bs, P-4806909 Braga - Portugal

• Tipo de documento: Artigo Científico
• Fonte: Oncology Letters; v. 16, n. 2, p. 1785-1790, AUG 2018.
• Citações Web of Science: 0

Resumo

There has been an increase in the incidence of anal cancer in the past two decades, with squamous cell carcinoma (SCC) being the most frequent histological type identified. Among the risk factors, high-risk human papillomavirus (HPV) infection is the most pervasive. Raf kinase inhibitor protein (RKIP) is expressed in a number of normal human tissues and previous studies have demonstrated the prognostic value of the loss of RKIP expression in several gastrointestinal tumors. Therefore, the present study aimed to evaluate the clinical implications of RKIP expression in a series of neoplastic lesions of the anal canal. The resected tumors of 48 patients {[}8 high-grade intraepithelial lesions (HSILs), 14 adenocarcinomas and 26 squamous cell carcinomas (SCCs)] were immunohistochemically evaluated for RKIP expression, and the results were correlated with clinicopathological data. The results identified a decreased 5-year overall survival rate in patients with adenocarcinoma (40.8%) compared with patients with SCC (76.7%), and a decreased 5-year disease-free survival rate in patients at clinical stages III/IV (37.3 vs. 62.5 and 82.6% for clinical stages 0 and I/II, respectively). Low RKIP expression was revealed in 62.5% of HSILs, 88.5% of SCCs and 100.0% of the adenocarcinomas. High RKIP expression was associated with patient ethnicity (37.5% in non-Caucasians vs. 7.5% in Caucasians) and patient age (33.3% in younger patients vs. 0.0% in older patients). Finally, high RKIP expression was correlated with HPV16 infection status (40% in HPV- vs. 5.3% in HPV+ patients). A correlation was identified between high RKIP expression and lesions with a generally improved prognosis, such as those diagnosed in younger patients, in situ lesions and lesions of lower clinical grades; there was also a negative correlation between high RKIP expression and HPV16 positivity in patients. (AU)

• Processo FAPESP: 10/16795-4 - Rastreamento de biomarcadores e do Papilomavírus humano em raspado celular de canal anal: correlação com infecção concomitante em colo uterino, cavidade oral e orofaringe
• Beneficiário: Adhemar Longatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/08523-7 - Perfil de alterações cromossômicas em tumores cerebrais (meduloblastomas e gliomas): impacto na identificação de novas vias tumorigênicas
• Beneficiário: Lucas Tadeu Bidinotto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado