Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines

Autor(es)

Komoto, Tatiana Takahasi ^[1] ; Bernardes, Tayna Minervina ^[1] ; Mesquita, Thais Balthazar ^[1] ; Buso Bortolotto, Luis Felipe ^[1] ; Silva, Gabriel ^{[1, 2]} ; Bitencourt, Tamires Aparecida ^[1] ; Baek, Seung Joon ^[2] ; Marins, Mozart ^[1] ; Fachin, Ana Lucia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Ribeirao Preto, Biotechnol Unit, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP - Brazil

^[2] Univ Tennessee, Coll Vet Med, Dept Biomed & Diagnost Sci, POB 1071, Knoxville, TN 37996 - USA

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 23, n. 8 AUG 2018.
• Citações Web of Science: 2

Resumo

In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins. (AU)

• Processo FAPESP: 16/22701-9 - "Estudo da resposta a antifúngicos e da interação fungo-hospedeiro do dermatofito Trichophyton rubrum utilizando diferentes modelos de infecção"
• Beneficiário: Ana Lucia Fachin Saltoratto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/23435-8 - Mecanismos moleculares envolvidos na resistência e na resposta adaptativa a inibidores fúngicos
• Beneficiário: Tamires Aparecida Bitencourt
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/15862-5 - Análise celular e molecular da resposta de células tumorais ao efeito de chalconas
• Beneficiário: Luis Felipe Buso Bortolotto
• Modalidade de apoio: Bolsas no Brasil - Mestrado