| Full text | |
| Author(s): |
Komoto, Tatiana Takahasi
[1]
;
Bernardes, Tayna Minervina
[1]
;
Mesquita, Thais Balthazar
[1]
;
Buso Bortolotto, Luis Felipe
[1]
;
Silva, Gabriel
[1, 2]
;
Bitencourt, Tamires Aparecida
[1]
;
Baek, Seung Joon
[2]
;
Marins, Mozart
[1]
;
Fachin, Ana Lucia
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Ribeirao Preto, Biotechnol Unit, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP - Brazil
[2] Univ Tennessee, Coll Vet Med, Dept Biomed & Diagnost Sci, POB 1071, Knoxville, TN 37996 - USA
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Molecules; v. 23, n. 8 AUG 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins. (AU) | |
| FAPESP's process: | 16/22701-9 - Study of the response to antifungal and fungal-host interaction of T.rubrum dermatophyte using different models of infection |
| Grantee: | Ana Lucia Fachin Saltoratto |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/23435-8 - Molecular mechanisms involved in resistance and adaptive response to fungal inhibitors |
| Grantee: | Tamires Aparecida Bitencourt |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 12/15862-5 - CELLULAR AND MOLECULAR ANALYSIS OF TUMOR CELLS IN RESPONSE TO THE EFFECT OF CHALCONE |
| Grantee: | Luis Felipe Buso Bortolotto |
| Support Opportunities: | Scholarships in Brazil - Master |