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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines

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Author(s):
Komoto, Tatiana Takahasi [1] ; Bernardes, Tayna Minervina [1] ; Mesquita, Thais Balthazar [1] ; Buso Bortolotto, Luis Felipe [1] ; Silva, Gabriel [1, 2] ; Bitencourt, Tamires Aparecida [1] ; Baek, Seung Joon [2] ; Marins, Mozart [1] ; Fachin, Ana Lucia [1]
Total Authors: 9
Affiliation:
[1] Univ Ribeirao Preto, Biotechnol Unit, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP - Brazil
[2] Univ Tennessee, Coll Vet Med, Dept Biomed & Diagnost Sci, POB 1071, Knoxville, TN 37996 - USA
Total Affiliations: 2
Document type: Journal article
Source: Molecules; v. 23, n. 8 AUG 2018.
Web of Science Citations: 2
Abstract

In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins. (AU)

FAPESP's process: 12/15862-5 - CELLULAR AND MOLECULAR ANALYSIS OF TUMOR CELLS IN RESPONSE TO THE EFFECT OF CHALCONE
Grantee:Luis Felipe Buso Bortolotto
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/23435-8 - Molecular mechanisms involved in resistance and adaptive response to fungal inhibitors
Grantee:Tamires Aparecida Bitencourt
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/22701-9 - Study of the response to antifungal and fungal-host interaction of T.rubrum dermatophyte using different models of infection
Grantee:Ana Lucia Fachin Saltoratto
Support type: Regular Research Grants