Relationship between fatty acids intake and Clostridium coccoides in obese individuals with metabolic syndrome

Autor(es)

Jamar, Giovana ^[1] ; Santamarina, Aline Boveto ^[1] ; Dias, Gabriela Correia ^[2] ; Landi Masquio, Deborah Cristina ^[4] ; de Rosso, Veridiana Vera ^[2] ; Pisani, Luciana Pellegrini ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Santos, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Biociencias, Inst Saude & Soc, Santos, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Gestao & Cuidados Saude, Santos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Food Research International; v. 113, p. 86-92, NOV 2018.
• Citações Web of Science: 4

Resumo

Dietary habits exert a strong influence on gut microbial composition and may result in an imbalance of gut microbes, representing a predisposition to obesity and metabolic disorders. We aimed to investigate a potential relationship between gut bacterial species and metabolic parameters and dietary intake. Bacterial DNA was extracted from feces of 34 obese subjects with and without metabolic syndrome (MS and n-MS group, respectively). We then used real-time polymerase chain reaction (qPCR) for quantifying specific sequences to Akkermansia muciniphila, Bifidobacterium spp., Clostridium coccoides, and Lactobacillus spp. and analyzed them with respect to clinical characteristics. Our data showed that the MS group had a 6.7-fold higher level of C. coccoides in their stool samples than the n-MS group. The abundance of C. coccoides was positively correlated with a high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids. Furthermore, an excessive dietary level of MUFA was identified as a predictor of C. coccoides abundance. Alterations in the gut microbial ecology were positively correlated with levels of triacylglycerol in obese individuals. Therefore, the type and quantity of dietary fat may alter the gut microbial ecology in obese individuals with MS and may predispose them to dyslipidemia. (AU)

• Processo FAPESP: 16/14133-0 - Mecanismos intracelulares envolvidos com o processo inflamatório em indivíduos obesos antes e após a suplementação de polpa de juçara (Euterpe edulis Mart.)
• Beneficiário: Luciana Pellegrini Pisani
• Modalidade de apoio: Auxílio à Pesquisa - Regular