Association between age at menarche and blood pressure in adulthood: is obesity an important mediator?

Autor(es)

Werneck, Andre O. ^{[1, 2]} ; Oyeyemi, Adewale L. ^[3] ; Cyrino, Edilson S. ^[1] ; Ronque, V, Enio R. ; Szwarcwald, Celia L. ^[4] ; Coelho-e-Silva, Manuel J. ^[5] ; Silva, Danilo R. ^[6]

Afiliação do(s) autor(es)

^[1] V, State Univ Londrina UEL, Study & Res Grp Metab Nutr & Exercise GEPEMENE, Londrina - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Phys Educ, Sci Res Grp Related Phys Act GICRAF, LIVE, Presidente Prudente - Brazil

^[3] Univ Maiduguri, Coll Med Sci, Dept Physiotherapy, Maiduguri, Bomo State - Nigeria

^[4] Fiocruz MS, Oswaldo Cruz Fdn, ICICT, Rio De Janeiro - Brazil

^[5] Univ Coimbra, FCDEF CIDAF Uid Dtp 04213 2016, Coimbra - Portugal

^[6] Fed Univ Sergipe UFS, Dept Phys Educ, Sao Cristovao - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HYPERTENSION RESEARCH; v. 41, n. 10, p. 856-864, OCT 2018.
• Citações Web of Science: 0

Resumo

We investigated the association between age at menarche, and adiposity and blood pressure in adulthood, as well as the mediation effects of adiposity on the relationship between age at menarche and blood pressure. This was a nationally representative survey conducted in Brazil in 2013 (Brazilian Health Survey). The participants included 33,715 women between 18 and 100 years old. Age at menarche was self-reported and outcomes (body mass index {[}BMI], waist circumference, and blood pressure) were objectively measured. As covariates, data on chronological age, race, educational status, tobacco smoking, leisure physical activity, TV viewing, sodium consumption, alcohol drinking, menopause status, and antihypertensive medication use were obtained by questionnaires. Negative and linear relationships were observed between age at menarche and adiposity indicators. Early maturers presented a greater prevalence of obesity (waist circumference: 56.3% {[}54.0-58.7] vs. 52.4% {[}51.4-53.5], BMI: 32.4% {[}30.2-34.6] vs. 25.1% {[}24.2-26.0]) than on time/late maturers. Age at menarche was significantly inversely related to blood pressure and adiposity in adulthood (p < 0.05), although these associations were weaker than the association between obesity and early menarche. Adiposity indicators mediated the relationship between age at menarche, and systolic (partly) and diastolic (fully) blood pressure. In conclusion, early maturation is related to obesity and higher blood pressure in adulthood. Obesity is an important mediator of the influence of early maturation on high blood pressure in women. (AU)

• Processo FAPESP: 17/27234-2 - Associação longitudinal entre maturação biológica, gordura corporal e prática esportiva na predição do risco de síndrome metabólica e proteína C-reativa: modelos de equação estrutural (ABCD - growth study)
• Beneficiário: André de Oliveira Werneck
• Modalidade de apoio: Bolsas no Brasil - Mestrado