Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial

Autor(es)

Ramiro, F. S. ^[1] ; de Lira, E. A. G. ^[1] ; Soares, G. M. S. ^[1] ; Retamal-Valdes, B. ^[1] ; Feres, M. ^[1] ; Figueiredo, L. C. ^[1] ; Faveri, M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Guarulhos, Dept Periodontol, Dent Res Div, Guarulhos - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF DENTAL HYGIENE; v. 16, n. 4, p. 569-575, NOV 2018.
• Citações Web of Science: 1

Resumo

Objective: The aim of this randomized double-blind and placebo-controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the mean level of Archaea. Methods: Fifty-nine (59) subjects were randomly assigned to receive scaling and root planing (SRP) alone or combined with metronidazole (MTZ; 400 mg/TID) or either with MTZ and amoxicillin (AMX; 500 mg/TID) for 14 days. Clinical and microbiological examinations were performed at baseline and at 6 months post-SRP. Six subgingival plaque samples per subject were analysed for the presence and levels of Archaea using quantitative polymerase chain reaction. Results: Scaling and root planing alone or combined with MTZ or MTZ+AMX significantly reduced the prevalence of subjects colonized by Archaea at 6 months post-therapy, without significant differences among groups (P>.05). Both therapies led to a statistically significant decrease in the mean percentage of sites colonized by Archaea (P<.05). The MTZ and MTZ+AMX group had a significantly lower mean number of sites colonized by Archaea and lower levels of these micro-organisms at sites with probing depth >= 5 mm at 6 months compared with SRP group (P<.05). Conclusion: Periodontal treatments including adjunctive MTZ or MTZ+AMX are more effective than mechanical treatment alone in reducing the levels and prevalence of sites colonized by Archaea in subjects with chronic periodontitis. (AU)

• Processo FAPESP: 13/10139-6 - Busca de espécies bacterianas ainda não cultivadas na etiologia da periodontite crônica e agressiva: estudo transversal
• Beneficiário: Marcelo de Faveri
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/23503-5 - Relação de espécies bacterianas ainda não cultivadas na etiologia da periodontite - Estudo transversal.
• Beneficiário: Renata Ramos Dias Silva de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado