Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial

Full text
Author(s):
Ramiro, F. S. [1] ; de Lira, E. A. G. [1] ; Soares, G. M. S. [1] ; Retamal-Valdes, B. [1] ; Feres, M. [1] ; Figueiredo, L. C. [1] ; Faveri, M. [1]
Total Authors: 7
Affiliation:
[1] Univ Guarulhos, Dept Periodontol, Dent Res Div, Guarulhos - Brazil
Total Affiliations: 1
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF DENTAL HYGIENE; v. 16, n. 4, p. 569-575, NOV 2018.
Web of Science Citations: 1
Abstract

Objective: The aim of this randomized double-blind and placebo-controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the mean level of Archaea. Methods: Fifty-nine (59) subjects were randomly assigned to receive scaling and root planing (SRP) alone or combined with metronidazole (MTZ; 400 mg/TID) or either with MTZ and amoxicillin (AMX; 500 mg/TID) for 14 days. Clinical and microbiological examinations were performed at baseline and at 6 months post-SRP. Six subgingival plaque samples per subject were analysed for the presence and levels of Archaea using quantitative polymerase chain reaction. Results: Scaling and root planing alone or combined with MTZ or MTZ+AMX significantly reduced the prevalence of subjects colonized by Archaea at 6 months post-therapy, without significant differences among groups (P>.05). Both therapies led to a statistically significant decrease in the mean percentage of sites colonized by Archaea (P<.05). The MTZ and MTZ+AMX group had a significantly lower mean number of sites colonized by Archaea and lower levels of these micro-organisms at sites with probing depth >= 5 mm at 6 months compared with SRP group (P<.05). Conclusion: Periodontal treatments including adjunctive MTZ or MTZ+AMX are more effective than mechanical treatment alone in reducing the levels and prevalence of sites colonized by Archaea in subjects with chronic periodontitis. (AU)

FAPESP's process: 13/10139-6 - Not-yet bacterial species in the aetiology of chronic and aggressive periodontitis: cross-section study
Grantee:Marcelo de Faveri
Support Opportunities: Regular Research Grants
FAPESP's process: 12/23503-5 - Not-yet bacterial species in the aetiology of periodontitis - Cross-section study
Grantee:Renata Ramos Dias Silva de Oliveira
Support Opportunities: Scholarships in Brazil - Master