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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Topological assessment of metabolic networks reveals evolutionary information

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Autor(es):
Machicao, Jeaneth [1] ; Filho, Humberto A. [1] ; Lahr, Daniel J. G. [2] ; Buckeridge, Marcos [2] ; Bruno, Odemir M. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Inst Biosci, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 8, OCT 29 2018.
Citações Web of Science: 0
Resumo

Evolutionary information was inferred from the topology of metabolic networks corresponding to 17 plant species belonging to major plant lineages Chlorophytes, Bryophytes, Lycophytes and Angiosperms. The plant metabolic networks were built using the substrate-product network modeling based on the metabolic reactions available on the PlantCyc database (version 9.5), from which their local topological properties such as degree, in-degree, out-degree, clustering coefficient, hub-score, authority-score, local efficiency, betweenness and eigencentrality were measured. The topological measurements corresponding to each metabolite within the networks were considered as a set of metabolic characters to compound a feature vector representing each plant. Our results revealed that some local topological characters are able to discern among plant kinships, since similar phylogenies were found when comparing dendrograms obtained by topological metrics to the one obtained by DNA sequences of chloroplast genes. Furthermore, we also found that even a smaller number of metabolic characters is able to separate among major clades with high bootstrap support (BS > 95), while for some suborders a bigger content has been required. (AU)

Processo FAPESP: 13/04585-3 - Decifrando as grandes tendências de evolução molecular e morfológica nos Amoebozoa
Beneficiário:Daniel José Galafasse Lahr
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 14/08026-1 - Visão artificial e reconhecimento de padrões aplicados em plasticidade vegetal
Beneficiário:Odemir Martinez Bruno
Linha de fomento: Auxílio à Pesquisa - Regular