The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas

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Kessler, R. C. ^[1] ; Aguilar-Gaxiola, S. ^[2] ; Alonso, J. ^{[3, 4]} ; Bromet, E. J. ^[5] ; Gureje, O. ^[6] ; Karam, E. G. ^{[7, 8]} ; Koenen, K. C. ^[9] ; Lee, S. ^[10] ; Liu, H. ^{[9, 1]} ; Pennell, B-E ^[11] ; Petukhova, M. V. ^[1] ; Sampson, N. A. ^[1] ; Shahly, V. ^[1] ; Stein, D. J. ^[12] ; Atwoli, L. ^{[12, 13]} ; Borges, G. ^[14] ; Bunting, B. ^[15] ; de Girolamo, G. ^[16] ; Gluzman, S. F. ^[17] ; Haro, J. M. ^[18] ; Hinkov, H. ^[19] ; Kawakami, N. ^[20] ; Kovess-Masfety, V. ^[21] ; Navarro-Mateu, F. ^[22] ; Posada-Villa, J. ^[23] ; Scott, K. M. ^[24] ; Shalev, A. Y. ^[25] ; ten Have, M. ^[26] ; Torres, Y. ^[27] ; Viana, M. C. ^[28] ; Zaslavsky, A. M. ^[1] ; Col, WHO World Mental Hlth Survey

Afiliação do(s) autor(es):Mostrar menos -

^[1] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA 02115 - USA

^[2] UC Davis Hlth Syst, Ctr Reducing Hlth Dispar, Sacramento, CA - USA

^[3] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona - Spain

^[4] Pompeu Fabra Univ UPF, IMIM, Hosp del Mar, Hlth Serv Res Unit, Res Inst, Parc Salut Mar, Barcelona - Spain

^[5] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 - USA

^[6] Univ Coll Hosp, Dept Psychiat, Ibadan - Nigeria

^[7] IDRAAC, Beirut - Lebanon

^[8] Balamand Univ, St George Hosp Univ, Med Ctr, Dept Psychiat & Clin Psychol, Fac Med, Beirut - Lebanon

^[9] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA

^[10] Chinese Univ Hong Kong, Dept Psychiat, Tai Po, Hong Kong - Peoples R China

^[11] Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI - USA

^[12] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town - South Africa

^[13] Moi Univ, Sch Med, Dept Mental Hlth, Eldoret - Kenya

^[14] Natl Inst Psychiat Ramon Fuente, Mexico City, DF - Mexico

^[15] Univ Ulster, Sch Psychol, Belfast, Londonderry - North Ireland

^[16] IRCCS Ctr S Giovanni Dio Fatebenefratelli, IRCCS St John God Clin Res Ctr, Brescia - Italy

^[17] Ukrainian Psychiat Assoc, Kiev - Ukraine

^[18] Univ Barcelona, CIBERSAM, Parc Sanitari St Joan de Deu, Barcelona - Spain

^[19] Natl Ctr Publ Hlth & Analyses, Sofia - Bulgaria

^[20] Univ Tokyo, Sch Publ Hlth, Dept Mental Hlth, Tokyo - Japan

^[21] Paris Descartes Univ, EHESP, EA 4057, Paris - France

^[22] CIBERESP Murcia, IMIB Arrixaca, Serv Murciano Salud, Subdirecc Gen Planificac Innovac & Cronicidad, UDI, Murcia - Spain

^[23] Colegio Mayor Cundinamarca Univ, Bogota - Colombia

^[24] Univ Otago, Dept Psychol Med, Dunedin - New Zealand

^[25] NYU, Dept Psychiat, Langone Med Ctr, 550 1St Ave, New York, NY 10016 - USA

^[26] Netherlands Inst Mental Hlth & Addict, Trimbos Inst, Utrecht - Netherlands

^[27] CES Univ, Ctr Excellence Res Mental Hlth, Medellin - Colombia

^[28] Univ Fed Espirito Santo, Dept Social Med, Vitoria - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MOLECULAR PSYCHIATRY; v. 23, n. 9 SEP 2018.
• Citações Web of Science: 7

Resumo

Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR) = 1.3-2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR = 1.5-4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR = 5.6). Histories of physical violence victimization (OR = 1.5) and rape after age 17 years (OR = 17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas. (AU)

• Processo FAPESP: 03/00204-3 - Estudo epidemiológico dos transtornos psiquiátricos na região metropolitana de São Paulo: prevalências, fatores de risco e sobrecarga social e econômica
• Beneficiário: Laura Helena Silveira Guerra de Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Temático