Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers: Probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres

Autor(es)

Pound-Lana, Gwenaelle E. N. ^[1] ; Garcia, Giani M. ^[1] ; Trindade, Izabel C. ^[1] ; Capelari-Oliveira, Patricia ^[1] ; Pontifice, Thais Godinho ^[1] ; Vilela, Jose Mario C. ^[2] ; Andrade, Margareth S. ^[2] ; Nottelet, Benjamin ^[3] ; Postacchini, Bruna B. ^[4] ; Mosqueira, Vanessa C. F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Ouro Preto, Sch Pharm, Lab Pharmaceut Dev & Nanobiotechnol, Campus Univ Morro Cruzeiro, BR-35400000 Ouro Preto, MG - Brazil

^[2] CIT Ctr Inovacao & Tecnol Senai Fierng, Ave Jose Candido Silveira 2000, BR-31035536 Belo Horizonte, MG - Brazil

^[3] Univ Montpellier, CNRS, ENSCM, IBMM, UMR 5247, Montpellier - France

^[4] Univ Fed Ouro Preto, Phys Dept, Lab Mol Photophys, Ouro Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 94, p. 220-233, JAN 1 2019.
• Citações Web of Science: 4

Resumo

For best photosensitizer activity phthalocyanine dyes used in photodynamic therapy should be molecularly dispersed. Polyethylene glycol-block-polylactide derivatives presenting benzyl side-groups were synthesized to encapsulate a highly lipophilic phthalocyanine dye (AlClPc) and evaluate the effect of pi-pi interactions on the nanocarrier colloidal stability and dye dispersion. Copolymers with 0, 1, 2 and 6 mol% of benzyl glycidyl ether (BGE) were obtained via polyethylene glycol initiated ring-opening copolymerization of D,L-lactide with BGE. The block copolymers formed stable, monodisperse nanospheres with low in vitro cytotoxicity. AlClPc loading increased the nanosphere size and affected their colloidal stability. The photo-physical properties of the encapsulated dye, studied in batch and after separation by field flow fractionation, demonstrated the superiority of plain PEG-PLA over BGE-containing copolymers in maintaining the dye in its monomeric (non-aggregated) form in aqueous suspension. High dye encapsulation and sustained dye release suggest that these nanocarriers are good candidates for photodynamic therapy. (AU)

• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático