Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial

Autor(es)

Rebelatto Bechara Andere, Naira Maria ^[1] ; Castro dos Santos, Nidia Cristina ^[1] ; Araujo, Cassia Fernandes ^[1] ; Mathias, Ingrid Fernandes ^[1] ; Rossato, Amanda ^[1] ; de Marco, Andrea Carvalho ^[1] ; Santamaria Jr, Milton ; Neves Jardini, Maria Aparecida ^[1] ; Santamaria, Mauro Pedrine ^[1]

Afiliação do(s) autor(es)

^[1] Unesp Sao Paulo State Univ, Div Periodontol, Coll Dent, FOSJC, Av Eng Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Photodiagnosis and Photodynamic Therapy; v. 24, p. 115-120, DEC 2018.
• Citações Web of Science: 1

Resumo

Background: This study's aim was to evaluate the local effect of clarithromycin associated with antimicrobial photodynamic therapy (aPDT) in the treatment of generalized aggressive periodontitis. Materials and methods: The study sample comprised 72 periodontal pockets on single-rooted teeth in multiple quadrants, with both probing depth and clinical attachment level >= 5 mm, and with bleeding on probing. The pockets were randomly distributed into four groups (n = 18 each) that received ultrasonic periodontal debridement in addition to placebo (the UPD group), systemic clarithromycin (the UPD + CLM group), aPDT (the UPD + aPDT group), or both systemic clarithromycin and aPDT (the UPD + CLM + aPDT group). The measurements were performed prior to treatment (baseline) and at 3 and 6 months postoperatively. The following parameters were evaluated: plaque index, bleeding on probing, probing depth, gingival recession, and clinical attachment level. A 5% significance level was used in the statistical analysis. Results: At 3 months, UPD + aPDT, UPD + CLM, and UPD + CLM + aPDT groups all exhibited reduced probing depths relative to the UPD group (p < 0.05). However, at 6 months, the reduction in mean probing depth was greater in the antibiotic groups (UPD + CLM and UPD + CLM + aPDT) than in the UPD and UPD + aPDT groups (p < 0.05). Regarding clinical attachment level, only the UPD + CLM + aPDT group presented a significant gain relative to the UPD and UPD + PDT groups (p < 0.05). Conclusions: Ultrasonic periodontal debridement has greater clinical advantages when associated with clarithromycin than with associated with aPDT. However, the joint application of aPDT and clarithromycin did not present additional benefits. (AU)

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• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
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• Modalidade de apoio: Auxílio à Pesquisa - Regular