Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial

Author(s)

Rebelatto Bechara Andere, Naira Maria ^[1] ; Castro dos Santos, Nidia Cristina ^[1] ; Araujo, Cassia Fernandes ^[1] ; Mathias, Ingrid Fernandes ^[1] ; Rossato, Amanda ^[1] ; de Marco, Andrea Carvalho ^[1] ; Santamaria Jr, Milton ; Neves Jardini, Maria Aparecida ^[1] ; Santamaria, Mauro Pedrine ^[1]

Affiliation

^[1] Unesp Sao Paulo State Univ, Div Periodontol, Coll Dent, FOSJC, Av Eng Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 24, p. 115-120, DEC 2018.
• Web of Science Citations: 1

Abstract

Background: This study's aim was to evaluate the local effect of clarithromycin associated with antimicrobial photodynamic therapy (aPDT) in the treatment of generalized aggressive periodontitis. Materials and methods: The study sample comprised 72 periodontal pockets on single-rooted teeth in multiple quadrants, with both probing depth and clinical attachment level >= 5 mm, and with bleeding on probing. The pockets were randomly distributed into four groups (n = 18 each) that received ultrasonic periodontal debridement in addition to placebo (the UPD group), systemic clarithromycin (the UPD + CLM group), aPDT (the UPD + aPDT group), or both systemic clarithromycin and aPDT (the UPD + CLM + aPDT group). The measurements were performed prior to treatment (baseline) and at 3 and 6 months postoperatively. The following parameters were evaluated: plaque index, bleeding on probing, probing depth, gingival recession, and clinical attachment level. A 5% significance level was used in the statistical analysis. Results: At 3 months, UPD + aPDT, UPD + CLM, and UPD + CLM + aPDT groups all exhibited reduced probing depths relative to the UPD group (p < 0.05). However, at 6 months, the reduction in mean probing depth was greater in the antibiotic groups (UPD + CLM and UPD + CLM + aPDT) than in the UPD and UPD + aPDT groups (p < 0.05). Regarding clinical attachment level, only the UPD + CLM + aPDT group presented a significant gain relative to the UPD and UPD + PDT groups (p < 0.05). Conclusions: Ultrasonic periodontal debridement has greater clinical advantages when associated with clarithromycin than with associated with aPDT. However, the joint application of aPDT and clarithromycin did not present additional benefits. (AU)

• FAPESP's process: 15/04621-5 - Treatment of generalized aggressive periodontitis associated or not with the use of clarithromycin: randomized clinical trial
• Grantee: Tamires Pereira Dutra
• Support type: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 15/12669-8 - Evaluation of the local effect of non-surgical periodontal treatment associated or not with systemic antibiotics and photodynamic therapy to treat generalized aggressive periodontitis: randomized clinical trial
• Grantee: Renata Silveira Sagnori
• Support type: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 12/14595-3 - The influence of low intensity laser therapy (LILT) in connective tissue graft for root coverage: a randomized-controlled clinical trial
• Grantee: Mauro Pedrine Santamaria
• Support type: Regular Research Grants