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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial

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Rebelatto Bechara Andere, Naira Maria [1] ; Castro dos Santos, Nidia Cristina [1] ; Araujo, Cassia Fernandes [1] ; Mathias, Ingrid Fernandes [1] ; Rossato, Amanda [1] ; de Marco, Andrea Carvalho [1] ; Santamaria Jr, Milton ; Neves Jardini, Maria Aparecida [1] ; Santamaria, Mauro Pedrine [1]
Total Authors: 9
[1] Unesp Sao Paulo State Univ, Div Periodontol, Coll Dent, FOSJC, Av Eng Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Photodiagnosis and Photodynamic Therapy; v. 24, p. 115-120, DEC 2018.
Web of Science Citations: 1

Background: This study's aim was to evaluate the local effect of clarithromycin associated with antimicrobial photodynamic therapy (aPDT) in the treatment of generalized aggressive periodontitis. Materials and methods: The study sample comprised 72 periodontal pockets on single-rooted teeth in multiple quadrants, with both probing depth and clinical attachment level >= 5 mm, and with bleeding on probing. The pockets were randomly distributed into four groups (n = 18 each) that received ultrasonic periodontal debridement in addition to placebo (the UPD group), systemic clarithromycin (the UPD + CLM group), aPDT (the UPD + aPDT group), or both systemic clarithromycin and aPDT (the UPD + CLM + aPDT group). The measurements were performed prior to treatment (baseline) and at 3 and 6 months postoperatively. The following parameters were evaluated: plaque index, bleeding on probing, probing depth, gingival recession, and clinical attachment level. A 5% significance level was used in the statistical analysis. Results: At 3 months, UPD + aPDT, UPD + CLM, and UPD + CLM + aPDT groups all exhibited reduced probing depths relative to the UPD group (p < 0.05). However, at 6 months, the reduction in mean probing depth was greater in the antibiotic groups (UPD + CLM and UPD + CLM + aPDT) than in the UPD and UPD + aPDT groups (p < 0.05). Regarding clinical attachment level, only the UPD + CLM + aPDT group presented a significant gain relative to the UPD and UPD + PDT groups (p < 0.05). Conclusions: Ultrasonic periodontal debridement has greater clinical advantages when associated with clarithromycin than with associated with aPDT. However, the joint application of aPDT and clarithromycin did not present additional benefits. (AU)

FAPESP's process: 15/04621-5 - Treatment of generalized aggressive periodontitis associated or not with the use of clarithromycin: randomized clinical trial
Grantee:Tamires Pereira Dutra
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/12669-8 - Evaluation of the local effect of non-surgical periodontal treatment associated or not with systemic antibiotics and photodynamic therapy to treat generalized aggressive periodontitis: randomized clinical trial
Grantee:Renata Silveira Sagnori
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/14595-3 - The influence of low intensity laser therapy (LILT) in connective tissue graft for root coverage: a randomized-controlled clinical trial
Grantee:Mauro Pedrine Santamaria
Support type: Regular Research Grants