Treatment of generalized aggressive periodontitis associated or not with the use of clarithromycin: randomized clinical trial

• Grant number: 15/04621-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): July 01, 2015
• Effective date (End): November 30, 2015
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Mauro Pedrine Santamaria
• Grantee: Tamires Pereira Dutra
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

Generalized aggressive periodontitis is a periodontal condition that may require the association of mechanical, scaling and root planning (SRP), with the use of antimicrobial agents in order to have better result in treating the disease. Several studies show the effectiveness of the use of amoxicillin (AMX) and metronidazole (MET) associated with SRP. However, the literature has already pointed that the extensive use these antimicrobials could generate bacterial resistance. In order to evaluate new approaches, the present randomized clinical trial aimed to assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. To this, 20 patients will be selected and randomly assigned into two groups: Test Group (SRP+C, n=10) will receive SRP associated with clarithromycin (500 mg - 12/12 hours) for 3 days; Control Group (SRP+P, n=10) will receive SRP associated with placebo. Probing depth (PD), gain in clinical attachment level (CAL) and bleeding probing will be avaluate at baseline, 3 and 6 months post- operatively.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REBELATTO BECHARA ANDERE, NAIRA MARIA; CASTRO DOS SANTOS, NIDIA CRISTINA; ARAUJO, CASSIA FERNANDES; MATHIAS, INGRID FERNANDES; ROSSATO, AMANDA; DE MARCO, ANDREA CARVALHO; SANTAMARIA JR, MILTON; NEVES JARDINI, MARIA APARECIDA; SANTAMARIA, MAURO PEDRINE. Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial. Photodiagnosis and Photodynamic Therapy, v. 24, p. 115-120, DEC 2018. (15/12669-8, 15/04621-5, 12/14595-3)

REBELATTO BECHARA ANDERE, NAIRA MARIA; CASTRO DOS SANTOS, NIDIA CRISTINA; ARAUJO, CASSIA FERNANDES; MATHIAS, INGRID FERNANDES; TAIETE, TIAGO; VIANA CASARIN, RENATO CORREA; NEVES JARDINI, MARIA APARECIDA; SHADDOX, LUCIANA MACHION; SANTAMARIA, MAURO PEDRINE. Clarithromycin as an Adjunct to One-Stage Full-Mouth Ultrasonic Periodontal Debridement in Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Trial. Journal of Periodontology, v. 88, n. 12, p. 1244-1252, DEC 2017. (15/12669-8, 15/04621-5)