Clarithromycin as an Adjunct to One-Stage Full-Mouth Ultrasonic Periodontal Debridement in Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Trial

Author(s)

Rebelatto Bechara Andere, Naira Maria ^[1] ; Castro dos Santos, Nidia Cristina ^[1] ; Araujo, Cassia Fernandes ^[1] ; Mathias, Ingrid Fernandes ^[1] ; Taiete, Tiago ^[2] ; Viana Casarin, Renato Correa ^[2] ; Neves Jardini, Maria Aparecida ^[1] ; Shaddox, Luciana Machion ^[3] ; Santamaria, Mauro Pedrine ^[1]

Affiliation

^[1] Sao Paulo State Univ, Div Periodontol, Dept Diag & Surg, Coll Dent, Sao Jose Dos Campos - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Div Periodont, Dept Prosthodont & Periodont, Piracicaba - Brazil

^[3] Univ Florida, Coll Dent, Dept Periodontol & Oral Biol, Gainesville, FL - USA

• Document type: Journal article
• Source: Journal of Periodontology; v. 88, n. 12, p. 1244-1252, DEC 2017.
• Web of Science Citations: 4

Abstract

Background: The aim of the present study is to evaluate the periodontal clinical and microbiologic responses and possible adverse effects of clarithromycin (CLM) combined with periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. Methods: Forty patients were selected and randomly assigned into one of two groups: 1) CLM (n = 20): one-stage full-mouth ultrasonic debridement (FMUD) associated with CLM (500 mg, every 12 hours for 3 days); and 2) placebo (n = 20): FMUD associated with placebo pills. Clinical and microbiologic parameters were evaluated at baseline and 3 and 6 months postoperatively. Results: Both treatments presented statistically significant clinical and microbiologic improvements. However, the CLM group presented lower means of probing depth for pockets >7 mm at 6 months (4.0 +/- 1.7 mm) compared with the placebo group (4.7 +/- 1.3 mm) (P = 0.04). In addition, the CLM group also presented greater reduction of Porphyromonas gingivalis (Pg) DNA counts at 6 months (P = 0.0001). Conclusion: Results from this study suggest both treatments are effective; however, adjunct use of CLM to FMUD leads to better reduction of deep pockets and Pg at 6 months compared with FMUD alone. (AU)

• FAPESP's process: 15/12669-8 - Evaluation of the local effect of non-surgical periodontal treatment associated or not with systemic antibiotics and photodynamic therapy to treat generalized aggressive periodontitis: randomized clinical trial
• Grantee: Renata Silveira Sagnori
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 15/04621-5 - Treatment of generalized aggressive periodontitis associated or not with the use of clarithromycin: randomized clinical trial
• Grantee: Tamires Pereira Dutra
• Support Opportunities: Scholarships in Brazil - Scientific Initiation