Evaluation of the local effect of non-surgical periodontal treatment associated or not with systemic antibiotics and photodynamic therapy to treat generalized aggressive periodontitis: randomized clinical trial

• Grant number: 15/12669-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2015
• Effective date (End): November 30, 2016
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Mauro Pedrine Santamaria
• Grantee: Renata Silveira Sagnori
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The aim of the present study was to evaluate the local effect of the antimicrobial therapy using Clarithromicyn association with photodynamic therapy (PDT) on the treatment of Generalizade Aggressive Periodontitis patients (GAgP). For this, 60 periodontal pockets in patients with GAgP in separate quadrants, with a probing depth (PD) and clinical attachment level of e 5mm, with bleeding on probing (BOP) on non-molar teeth will be selected to participate in the study. The pockets will be randomly distributed on the following groups: DP (n=15): periodontal pockets that will receive periodontal debridement and placebo; DP+CLM (n=15): periodontal pockets that will receive periodontal debridement associated with the use of systemic Clarithromycin; DP+PDT (n=15): periodontal pockets that will receive periodontal debridement associated with the use of photodynamic therapy; DP+CLM+PDT (n=15): periodontal pockets that will receive periodontal debridement associated with the use of Clarithromycin and photodynamic therapy. The evaluations will be performed prior to treatment (baseline), after three and six months. The following parameters will be evaluated: 1 Plaque Index; 2. Gingival Index; 3. Probing Depth (PD), from the pocket depth to the gingival margin performed with North Carolina periodontal probe (UNC- ,Hu-Friedy); 4. Gingival Recession (GR), as the gingival margin to the cementoenamel junction; 5. Clinical Attachment Level (CAL), PD+GR. 5% significance level will be assumed for statistical analysis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REBELATTO BECHARA ANDERE, NAIRA MARIA; CASTRO DOS SANTOS, NIDIA CRISTINA; ARAUJO, CASSIA FERNANDES; MATHIAS, INGRID FERNANDES; ROSSATO, AMANDA; DE MARCO, ANDREA CARVALHO; SANTAMARIA JR, MILTON; NEVES JARDINI, MARIA APARECIDA; SANTAMARIA, MAURO PEDRINE. Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial. Photodiagnosis and Photodynamic Therapy, v. 24, p. 115-120, DEC 2018. (15/12669-8, 15/04621-5, 12/14595-3)

REBELATTO BECHARA ANDERE, NAIRA MARIA; CASTRO DOS SANTOS, NIDIA CRISTINA; ARAUJO, CASSIA FERNANDES; MATHIAS, INGRID FERNANDES; TAIETE, TIAGO; VIANA CASARIN, RENATO CORREA; NEVES JARDINI, MARIA APARECIDA; SHADDOX, LUCIANA MACHION; SANTAMARIA, MAURO PEDRINE. Clarithromycin as an Adjunct to One-Stage Full-Mouth Ultrasonic Periodontal Debridement in Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Trial. Journal of Periodontology, v. 88, n. 12, p. 1244-1252, DEC 2017. (15/12669-8, 15/04621-5)