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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A Novel Highly Divergent Strain of Cell Fusing Agent Virus (CFAV) in Mosquitoes from the Brazilian Amazon Region

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Autor(es):
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Fernandes, Licia Natal [1] ; Coletti, Thais de Moura [1] ; Costa Monteiro, Fred Julio [2] ; da Silva Rego, Marlisson Octavio [2] ; D'Athaide Ribeiro, Edcelha Soares [2] ; Ribeiro, Geovani de Oliveira [3] ; Souza Marinho, Robson dos Santos [4] ; Komninakis, Shirley Vasconcelos [4, 5] ; Witkin, Steven S. [6, 7] ; Deng, Xutao [8, 9] ; Delwart, Eric [8, 9] ; Sabino, Ester Cerdeira [6, 10] ; Leal, Elcio [3] ; da Costa, Antonio Charlys [6]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Lab Protozool, Inst Trop Med, BR-05403000 Sao Paulo, SP - Brazil
[2] Superintendence Hlth Survaillance Amapa, Lab Vectors, BR-68905230 Macapa, AP - Brazil
[3] Fed Univ Para, Inst Biol Sci, BR-66075000 Belem, Para - Brazil
[4] Univ Fed Sao Paulo, Lab Retrovirol, BR-04039032 Sao Paulo, SP - Brazil
[5] ABC, Fac Med, BR-09060870 Santo Andre, SP - Brazil
[6] Univ Sao Paulo, Inst Trop Med, BR-05403000 Sao Paulo, SP - Brazil
[7] Weill Cornell Med, Dept Obstet & Gynecol, New York, NY 10065 - USA
[8] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 - USA
[9] Vitalant Res Inst, 270 Masonic Ave, San Francisco, CA 94118 - USA
[10] Univ Sao Paulo, Fac Med, Dept Infect Dis, BR-01246903 Sao Paulo, SP - Brazil
Número total de Afiliações: 10
Tipo de documento: Artigo Científico
Fonte: Viruses-Basel; v. 10, n. 12 DEC 2018.
Citações Web of Science: 1
Resumo

Classical insect-specific flaviviruses (cISFs) have been widely detected in different countries in the last decades. Here, we characterize the near full-length genomes of two cISFs detected in mosquitoes collected in the city of Macapa, state of Amapa, Amazon region of Brazil. A total of 105 pools of female mosquitos were analyzed by next-generation sequencing (NGS). Comparative genomics and phylogenetic analysis identified three strains of cell fusing agent virus (CFAV) and two of Culex flavivirus (CxFV). All sequences were obtained from pools of Culex sp., except for one sequence of CFAV detected in a pool of Aedes aegypti. Both CxFV strains are phylogenetically related to a strain isolated in 2012 in the Southeast region of Brazil. The CFAV strains are the first of this species to be identified in Brazil and one of them is highly divergent from other strains of CFAV that have been detected worldwide. In conclusion, CFAV and CxFV, circulate in mosquitoes in Brazil. One strain of CFAV is highly divergent from others previously described, suggesting that a novel strain of CFAV is present in this region. (AU)

Processo FAPESP: 16/18204-0 - Identificação de Flavivirus e Alphavirus em mosquitos (Diptera: Culicidae) coletados em áreas verdes da cidade de São Paulo
Beneficiário:Thaís de Moura Coletti
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 17/00021-9 - Metagenômica viral da dengue, Chikungunya e Zika: acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil
Beneficiário:Antonio Charlys da Costa
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/01735-2 - Metagenômica viral de dengue, Chikungunya e Zika vírus: acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil
Beneficiário:Ester Cerdeira Sabino
Linha de fomento: Auxílio à Pesquisa - Regular