Effect of Costus spiralis (Jacq.) Roscoe Leaves, Methanolic Extract and Guaijaverin on Blood Glucose and Lipid Levels in a Type II Diabetic Rat Model

Autor(es):Mostrar menos -

Duarte, Regiane C. ^{[1, 2]} ; Taleb-Contini, Silvia H. ^[1] ; Pereira, Paulo S. ^[3] ; Oliveira, Camila F. ^[1] ; Miranda, Carlos Eduardo S. ^[1] ; Bertoni, Bianca W. ^[1] ; Coppede, Juliana S. ^[1] ; Willrich, Guilherme B. ^[4] ; Crevelin, Eduardo J. ^[4] ; Franca, Suzelei C. ^[1] ; Pereira, Ana Maria S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Ribeirao Preto UNAERP, Unidade Biotecnol, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP - Brazil

^[2] Univ Estadual Santa Cruz UESC, Dept Ciencias Saude, Rod Jorge Amado Km 16, BR-45662900 Ilheus, BA - Brazil

^[3] Inst Fed Educ Ciencia & Tecnol Goias, Programa Posgrad Agroquim, Zona Rural, Campus Rio Verde, Rod Sul Goiana Km 01, POB 66970, BR-7590 Rio Verde, Go - Brazil

^[4] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRY & BIODIVERSITY; v. 16, n. 1 JAN 2019.
• Citações Web of Science: 0

Resumo

This study aimed to isolate and identify flavonoids with hypoglycemic activity in Costus spiralis leaves. The methanolic extract (ME) was rich in flavonoids, while the powdered leaves (PL) contained considerable amounts of macro- and microelements. Oral acute treatment of streptozotocin (STZ)-induced diabetic rats for 18 h with the C. spiralis PL, ME and isolated guaijaverin (GUA) lowered glycemia, improved oral glucose tolerance and inhibited liver lipid peroxidation. GUA and ME lowered plasma levels of low-density and non-high density lipoproteins; GUA also lowered total cholesterol levels. PL, ME and GUA did not significantly alter the plasma levels of triglycerides, high-density lipoproteins, very low-density lipoproteins, creatinine and aspartate transaminase, and the total protein levels in the kidney and liver tissues. Therefore, C. spiralis leaves are promising raw materials and rich sources of bioactive flavonoids for the development of novel antidiabetic drugs due to their hypoglycemic, antidyslipidemic and antioxidant actions. (AU)

• Processo FAPESP: 10/01469-4 - Prospecção continuada de bioatividade de metabólitos para agregar valor a extratos de plantas brasileiras.
• Beneficiário: Paulo Sérgio Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Regular