Targeting Groups Employed in Selective Dendrons and Dendrimers

Autor(es)

Gonzaga, Rodrigo Vieira ^[1] ; Santos, Soraya da Silva ^[1] ; da Silva, Joao Vitor ^[1] ; Prieto, Diego Campos ^[1] ; Savino, Debora Feliciano ^[1] ; Giarolla, Jeanine ^[1] ; Ferreira, Elizabeth Igne ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PHARMACEUTICS; v. 10, n. 4 DEC 2018.
• Citações Web of Science: 2

Resumo

The design of compounds with directed action to a defined organ or tissue is a very promising approach, since it can decrease considerably the toxicity of the drug/bioactive compound. For this reason, this kind of strategy has been greatly important in the scientific community. Dendrimers, on the other hand, comprise extremely organized macromolecules with many peripheral functionalities, stepwise controlled synthesis, and defined size. These nanocomposites present several biological applications, demonstrating their efficiency to act in the pharmaceutical field. Considering that, the main purpose of this review was describing the potential of dendrons and dendrimers as drug targeting, applying different targeting groups. This application has been demonstrated through interesting examples from the literature considering the last ten years of publications. (AU)

• Processo FAPESP: 15/19438-1 - Síntese e estudos de liberação de compostos bioativos a partir de pró-fármacos e fármacos dirigidos dendriméricos potencialmente ativos em doenças negligenciadas
• Beneficiário: Jeanine Giarolla Vargas
• Modalidade de apoio: Auxílio à Pesquisa - Regular