| Full text | |
| Author(s): |
Gonzaga, Rodrigo Vieira
[1]
;
Santos, Soraya da Silva
[1]
;
da Silva, Joao Vitor
[1]
;
Prieto, Diego Campos
[1]
;
Savino, Debora Feliciano
[1]
;
Giarolla, Jeanine
[1]
;
Ferreira, Elizabeth Igne
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Fac Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Review article |
| Source: | PHARMACEUTICS; v. 10, n. 4 DEC 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
The design of compounds with directed action to a defined organ or tissue is a very promising approach, since it can decrease considerably the toxicity of the drug/bioactive compound. For this reason, this kind of strategy has been greatly important in the scientific community. Dendrimers, on the other hand, comprise extremely organized macromolecules with many peripheral functionalities, stepwise controlled synthesis, and defined size. These nanocomposites present several biological applications, demonstrating their efficiency to act in the pharmaceutical field. Considering that, the main purpose of this review was describing the potential of dendrons and dendrimers as drug targeting, applying different targeting groups. This application has been demonstrated through interesting examples from the literature considering the last ten years of publications. (AU) | |
| FAPESP's process: | 15/19438-1 - Synthesis and studies of bioactive compounds release from dendrimer prodrugs and targeted drugs potentially active in neglected diseases |
| Grantee: | Jeanine Giarolla Vargas |
| Support Opportunities: | Regular Research Grants |