Evaluation of the sintering temperature on the mechanical behavior of beta-tricalcium phosphate/calcium silicate scaffolds obtained by gelcasting method

Autor(es)

de Siqueira, Lilian ^[1] ; de Paula, Cynthia Guimardes ^[1] ; Gouveia, Rubia Figueredo ^[2] ; Motisuke, Mariana ^[1] ; Triches, Eliandra de Sousa ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol ICT, Lab Bioceram BIOCERAM, BR-12231280 Sao Jose Dos Campos, SP - Brazil

^[2] Natl Nanotechnol Lab LNNANO, Natl Ctr Energy & Mat CNPEM, POB 6192, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS; v. 90, p. 635-643, FEB 2019.
• Citações Web of Science: 2

Resumo

Scaffolds have been studied during the last decades as an alternative method to repair tissues. They are porous structures that act as a substrate for cellular growth, proliferation and differentiation. In this study, scaffolds of beta-tricalcium phosphate with calcium silicate fibers were prepared by gel casting method in order to be characterized and validated as a better choice for bone tissue treatment. Gel-casting led to scaffolds with high porosity (84%) and pores sizes varying from 160 to 500 pm, which is an important factor for the neovascularization of the growing tissue. Biocompatible and bioactive calcium silicate fibers, which can be successfully produced by molten salt method, were added into the scaffolds as a manner to improve its mechanical resistance and bioactivity. The addition of 5 wt% of calcium silicate fibers associated with a higher sintering temperature (1300 degrees C) increased by 64.6% the compressive strength of the scaffold and it has also led to the formation of a dense and uniform apatite layer after biomineralization assessment. (AU)

• Processo FAPESP: 10/00863-0 - Processamento e caracterização de suportes porosos nanoestruturados do tipo B-TCP/Al2O3 para aplicações biomédicas
• Beneficiário: Eliandra de Sousa Trichês
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/09240-9 - Otimização de cimentos de fosfato de cálcio para aplicação na ortopedia e na engenharia tecidual
• Beneficiário: Mariana Motisuke
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/07897-3 - Preparação e caracterização de scaffolds de beta-fosfato tricálcico reforçados com whiskers de silicato de cálcio
• Beneficiário: Cynthia Guimarães de Paula
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica