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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of the sintering temperature on the mechanical behavior of beta-tricalcium phosphate/calcium silicate scaffolds obtained by gelcasting method

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Author(s):
de Siqueira, Lilian [1] ; de Paula, Cynthia Guimardes [1] ; Gouveia, Rubia Figueredo [2] ; Motisuke, Mariana [1] ; Triches, Eliandra de Sousa [1]
Total Authors: 5
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol ICT, Lab Bioceram BIOCERAM, BR-12231280 Sao Jose Dos Campos, SP - Brazil
[2] Natl Nanotechnol Lab LNNANO, Natl Ctr Energy & Mat CNPEM, POB 6192, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS; v. 90, p. 635-643, FEB 2019.
Web of Science Citations: 2
Abstract

Scaffolds have been studied during the last decades as an alternative method to repair tissues. They are porous structures that act as a substrate for cellular growth, proliferation and differentiation. In this study, scaffolds of beta-tricalcium phosphate with calcium silicate fibers were prepared by gel casting method in order to be characterized and validated as a better choice for bone tissue treatment. Gel-casting led to scaffolds with high porosity (84%) and pores sizes varying from 160 to 500 pm, which is an important factor for the neovascularization of the growing tissue. Biocompatible and bioactive calcium silicate fibers, which can be successfully produced by molten salt method, were added into the scaffolds as a manner to improve its mechanical resistance and bioactivity. The addition of 5 wt% of calcium silicate fibers associated with a higher sintering temperature (1300 degrees C) increased by 64.6% the compressive strength of the scaffold and it has also led to the formation of a dense and uniform apatite layer after biomineralization assessment. (AU)

FAPESP's process: 10/00863-0 - Processing and characterization of B-TCP/Al2O3 nanostructured scaffolds for biomedical applications
Grantee:Eliandra de Sousa Trichês
Support Opportunities: Regular Research Grants
FAPESP's process: 11/09240-9 - Calcium phosphate cement otimization for application in orthopedics and tissue engineering
Grantee:Mariana Motisuke
Support Opportunities: Regular Research Grants
FAPESP's process: 12/07897-3 - Processing and characterization of calcium silicate whiskers reinforced beta-tricalcium phosphate scaffolds
Grantee:Cynthia Guimarães de Paula
Support Opportunities: Scholarships in Brazil - Scientific Initiation