Processing and characterization of B-TCP/Al2O3 nanostructured scaffolds for biomedical applications

• Grant number: 10/00863-0
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2011
• End date: February 28, 2013
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Eliandra de Sousa Trichês
• Grantee: Eliandra de Sousa Trichês
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
• Associated researchers: Cristina Pacheco Soares ; Kátia Regina Cardoso

Abstract

The development of three-dimensional porous materials that serve as support for cell growth is the particular interest of the regenerative engineering and tissue engineering due to the ability of these materials to mimic the natural conditions of extracellular matrix in terms of structure, chemical composition and mechanical properties. The development of these supports involves not only the use of biocompatible materials, but also of biodegradable materials, which must be properly processed to obtain porous matrices with appropriate morphology. Among the ceramics based on calcium phosphate, the tricalcium phosphate (TCP) in its polymorphic form ² (²-TCP), which is a bioabsorbable ceramic, has proved to be more suitable for use as temporary implants, because it presents good chemical stability and better biosorption rate. However, one of the disadvantages presented by this bioceramic is its reduced mechanical strength. An alternative to improve the mechanical properties of ²-TCP is the development of composite materials through the addition of a reinforcing phase. The biological and mechanical properties of the biocomposites can be improved by nanotechnology. In the case of nanostructured bioceramics, superior mechanical properties and surface characteristics favorable for osseointegration can be found. They can also be sintered at a lower temperature, minimizing the problems associated with phase transformation temperature (Beta to Alpha). In this context, the main purpose of this work focuses on the preparation of TCP/Al2O3 nanostructured scaffolds for biomedical applications. The supports will be characterized as their physical and mechanical properties. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LILIAN SIQUEIRA; CYNTHIA GUIMARÃES DE PAULA; MARIANA MOTISUKE; RUBIA FIGUEREDO GOUVEIA; SAMIRA ESTEVES AFONSO CAMARGO; NOALA VICENSOTO MOREIRA MILHAN; ELIANDRA DE SOUSA TRICHÊS. Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 20, n. 4, p. 973-983, 2017-05-22. (10/00863-0)

LOPES, JOAO H.; SOUZA, LUCAS P.; DOMINGUES, JULIANA A.; FERREIRA, V, FILIPE; HAUSEN, MOEMA DE ALENCAR; CAMILLI, JOSE A.; MARTIN, RICHARD A.; DE REZENDE DUEK, ELIANA A.; MAZALI, ITALO O.; BERTRAN, CELSO A.. In vitro and in vivo osteogenic potential of niobium-doped 45S5 bioactive glass: A comparative study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, OCT 2019. (10/05394-9, 11/17877-7, 10/00863-0, 11/09240-9)

DE SIQUEIRA, LILIAN; DE PAULA, CYNTHIA GUIMARDES; GOUVEIA, RUBIA FIGUEREDO; MOTISUKE, MARIANA; TRICHES, ELIANDRA DE SOUSA. Evaluation of the sintering temperature on the mechanical behavior of beta-tricalcium phosphate/calcium silicate scaffolds obtained by gelcasting method. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 90, p. 635-643, FEB 2019. (10/00863-0, 11/09240-9, 12/07897-3)

RENO, CAROLINE DE OLIVEIRA; PERETA, NICHOLAS C.; BERTRAN, CELSO A.; MOTISUKE, MARIANA; DE SOUSA, ELIANDRA. Study of in vitro degradation of brushite cements scaffolds. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 25, n. 10, p. 2297-2303, OCT 2014. (10/00863-0, 11/09240-9, 12/21198-0)

SOUZA, LUCAS; LOPES, JOAO HENRIQUE; ENCARNACAO, DAVI; MAZALI, ITALO ODONE; MARTIN, RICHARD ALAN; CAMILLI, JOSE ANGELO; BERTRAN, CELSO APARECIDO. Comprehensive in vitro and in vivo studies of novel melt-derived Nb-substituted 45S5 bioglass reveal its enhanced bioactive properties for bone healing. SCIENTIFIC REPORTS, v. 8, AUG 24 2018. (10/00863-0, 11/09240-9, 11/17877-7)

LOPES, JOAO H.; SOUZA, LUCAS P.; DOMINGUES, JULIANA A.; FERREIRA, V, FILIPE; HAUSEN, MOEMA DE ALENCAR; CAMILLI, JOSE A.; MARTIN, RICHARD A.; DE REZENDE DUEK, ELIANA A.; MAZALI, ITALO O.; BERTRAN, CELSO A.. In vitro and in vivo osteogenic potential of niobium-doped 45S5 bioactive glass: A comparative study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 108, n. 4, p. 1372-1387, MAY 2020. (11/17877-7, 11/09240-9, 10/05394-9, 10/00863-0)

LILIAN DE SIQUEIRA; FÁBIO ROBERTO PASSADOR; ANDERSON OLIVEIRA LOBO; ELIANDRA DE SOUSA TRICHÊS. Morphological, thermal and bioactivity evaluation of electrospun PCL/β-TCP fibers for tissue regeneration. POLIMEROS-CIENCIA E TECNOLOGIA, v. 29, n. 1, 2019-03-18. (10/00863-0, 11/17877-7)

LOPES, JOAO HENRIQUE; MAGALHAE, JESSICA APARECIDA; GOUUEIA, RUBIA FIGUEREDO; BERTRAN, CELSO APARECIDO; MOTISUKE, MARIANA; CAMARGO, SAMIRA E. A.; TRICHES, ELIANDRA DE SOUSA. Hierarchical structures of beta-TCP/45S5 bioglass hybrid scaffolds prepared by gelcasting. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 62, p. 10-23, SEP 2016. (10/00863-0, 11/09240-9, 11/17877-7)

SIQUEIRA, LILIAN; DE PAULA, CYNTHIA GUIMARAES; MOTISUKE, MARIANA; GOUVEIA, RUBIA FIGUEREDO; AFONSO CAMARGO, SAMIRA ESTEVES; MOREIRA MILHAN, NOALA VICENSOTO; TRICHES, ELIANDRA DE SOUSA. Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 20, n. 4, p. 973-983, JUL-AUG 2017. (10/00863-0)

DE SIQUEIRA, LILIAN; PASSADOR, FABIO ROBERTO; LOBO, ANDERSON OLIVEIRA; TRICHES, ELIANDRA DE SOUSA. Morphological, thermal and bioactivity evaluation of electrospun PCL/beta-TCP fibers for tissue regeneration. POLIMEROS-CIENCIA E TECNOLOGIA, v. 29, n. 1, 2019. (11/17877-7, 10/00863-0)