Use of high energy ball milling and porosity control in the development of Ti-Nb-Z...
| Grant number: | 10/00863-0 |
| Support type: | Regular Research Grants |
| Duration: | March 01, 2011 - February 28, 2013 |
| Field of knowledge: | Engineering - Biomedical Engineering |
| Principal Investigator: | Eliandra de Sousa Trichês |
| Grantee: | Eliandra de Sousa Trichês |
| Home Institution: | Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil |
| Assoc. researchers: | Cristina Pacheco Soares ; Kátia Regina Cardoso |
Abstract
The development of three-dimensional porous materials that serve as support for cell growth is the particular interest of the regenerative engineering and tissue engineering due to the ability of these materials to mimic the natural conditions of extracellular matrix in terms of structure, chemical composition and mechanical properties. The development of these supports involves not only the use of biocompatible materials, but also of biodegradable materials, which must be properly processed to obtain porous matrices with appropriate morphology. Among the ceramics based on calcium phosphate, the tricalcium phosphate (TCP) in its polymorphic form ² (²-TCP), which is a bioabsorbable ceramic, has proved to be more suitable for use as temporary implants, because it presents good chemical stability and better biosorption rate. However, one of the disadvantages presented by this bioceramic is its reduced mechanical strength. An alternative to improve the mechanical properties of ²-TCP is the development of composite materials through the addition of a reinforcing phase. The biological and mechanical properties of the biocomposites can be improved by nanotechnology. In the case of nanostructured bioceramics, superior mechanical properties and surface characteristics favorable for osseointegration can be found. They can also be sintered at a lower temperature, minimizing the problems associated with phase transformation temperature (Beta to Alpha). In this context, the main purpose of this work focuses on the preparation of TCP/Al2O3 nanostructured scaffolds for biomedical applications. The supports will be characterized as their physical and mechanical properties. (AU)