|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||July 01, 2012|
|Effective date (End):||June 30, 2013|
|Field of knowledge:||Engineering - Biomedical Engineering - Bioengineering|
|Principal Investigator:||Eliandra de Sousa Trichês|
|Grantee:||Cynthia Guimarães de Paula|
|Home Institution:||Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil|
Scaffolds are defined as supports which serve as substrate for the cellular growth, proliferation and differentiation, thus they must be biocompatible, to have optimum degradation rates, and to show porosity and interconnectivity, and favorable mechanical and biological properties for the tissue growth. One of the processing techniques for producing this class of material it is gel casting method associated to the aeration of ceramic suspension. This method consist of gelation the suspension by in situ polymerization of monomers soluble in water, which create a rigid cell body, with high green strength, porosity up to 95% and cells that tend to sphericity and pore size between 50-600 µm. The porosity, the pore size and its interconnectivity have great importance to the scaffold performance because they play a fundamental role in the new tissue formation. To avoid a loss of mechanical properties with increasing porosity, it is necessary an adjustment between both properties. In the fabrication of scaffolds for the bone tissue therapy, calcium phosphates, more specifically beta-tricalcium phosphate (beta-TCP), has received researchers attention because its reabsorption, morphology and chemical composition similar to bone mineral phase. The aim of this work is to evaluate the effect of whiskers calcium silicate (wollastonite) addition on physical and mechanical properties of beta-TCP scaffolds produced by gel casting method. The morphological, physical and mechanical properties of scaffolds will be determined and their mass loss in saline solution will also be assessed.