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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Exposure to tobacco smoke during the early postnatal period modifies receptors and enzymes of the endocannabinoid system in the brainstem and striatum in mice

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Autor(es):
Torres, Larissa Helena [1, 2] ; Balestrin, Natalia Trigo [1] ; Wiazowski Spelta, Liclia Emmanuela [1] ; Duro, Stephanie de Oliveira [1] ; Pistis, Marco [3, 4] ; Marcourakis, Tania [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Av Prof Lineu Prestes 580, Bloco 13B, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Fed Alfenas, Sch Pharmaceut Sci, Dept Food & Drugs, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG - Brazil
[3] Univ Cagliari, Dept Biomed Sci, I-09042 Monserrato, CA - Italy
[4] Univ Cagliari, CNR, Inst Neurosci, I-09042 Monserrato, CA - Italy
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Toxicology Letters; v. 302, p. 35-41, MAR 1 2019.
Citações Web of Science: 2
Resumo

Environmental tobacco smoke (ETS) exposure during brain development has been associated with several disorders, such as depression, anxiety, sudden infant death syndrome, and the predisposition to addiction. The endocannabinoid system plays an essential role in neuronal development. We investigated the effects of early postnatal ETS exposure on the endocannabinoid system in different brain regions. C57BL/6 J mice were exposed to ETS that was generated from 3R4F cigarettes from postnatal day 3 (P3) to P14. Receptors and enzymes of the endocannabinoid system were assessed in infancy, adolescence, and adulthood by Western blot. In the brain-stem, ETS exposure decreased cannabinoid 1 (CB1) receptor, CB2 receptor, N-arachidonoyl phosphatidyl ethanol-specific phospholipase D (NAPE-PLD), and fatty acid amino hydrolase (FAAH) levels and increased in diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) levels during infancy and decreased CB2 and FAAH levels during adulthood. In the striatum, ETS decreased in the NAPE-PLD and MAGL levels and increased FAAH levels during infancy, increased FAAH levels during adolescence, and decreased NAPE-PLD levels during adulthood. The present findings indicate that exposure to ETS during a critical period of brain development can disturb the endocannabinoid system in the brainstem and striatum, regions that are involved in the pathogenesis of sudden infant death syndrome and the susceptibility to addiction. (AU)

Processo FAPESP: 13/12769-7 - Exposição à fumaça do cigarro no início do período pós-natal de roedores: implicações na plasticidade sináptica e no sistema endocanabinoide.
Beneficiário:Larissa Helena Lobo Torres Pacheco
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado