Eplingiella fruticosa leaf essential oil complexed with beta-cyclodextrin produces a superior neuroprotective and behavioral profile in a mice model of Parkinson's disease

Autor(es):Mostrar menos -

Beserra-Filho, Jose I. A. ^[1] ; de Macedo, Amanda M. ^[1] ; Leao, Anderson H. F. F. ^[2] ; Bispo, Jose Marcos M. ^[3] ; Santos, Jose R. ^[3] ; de Oliveira-Melo, Allan John ^[4] ; Menezes, Paula dos Passos ^[4] ; Duarte, Marcelo C. ^[4] ; de Souza Araujo, Adriano A. ^[4] ; Silva, Regina H. ^[2] ; Quintans-Junior, Lucindo J. ^[4] ; Ribeiro, Alessandra M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Biosci, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Pharmacol, Edificio Jose Leal Prado, Rua Botucatu 862, BR-04023062 Sao Paulo, SP - Brazil

^[3] Univ Fed Sergipe, Dept Biosci, Ave Ver Olimpio Grande S-N, BR-49500000 Itabaiana, SE - Brazil

^[4] Univ Fed Sergipe, Dept Physiol, Ave Marechal Rondon S-N, BR-49100000 Aracaju, SE - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food and Chemical Toxicology; v. 124, p. 17-29, FEB 2019.
• Citações Web of Science: 1

Resumo

Evidence indicates that oxidative stress has an important role in the onset and progression of Parkinson's disease (PD). Antioxidant agents from natural products have shown neuroprotective effects in animal models of PD. Eplingiella fruticosa is an aromatic and medicinal plant of the Lamiaceae family that include culinary herbs. The essential oil (EPL) has anti-inflammatory and antioxidant activities. Cyclodextrins are used to enhances pharmacological profile of essential oil. We obtained the EPL from leaves and complexed with beta-cyclodextrin (EPL-beta CD). Phytochemical analysis showed as main constituents: beta-caryophyllene, bicyclogermacrene and 1,8-cineole. We evaluated the effects of EPL and EPL-beta CD (5 mg/kg, p.o. for 40 days) on male mice submitted to the progressive reserpine PD model. Behavioral evaluations, lipid peroxidation quantification and immunohistochemistry for tyrosine hydroxylase were conducted. EPL delayed the onset of catalepsy and decreased membrane lipid peroxides levels in the striatum. EPL-beta CD also delayed the onset of catalepsy, reduced the frequency of oral diskynesia, restored memory deficit, produced anxiolytic activity and protected against dopaminergic depletion in the striatum and SNpc. These findings showed that EPL has a potential neuroprotective effect in a progressive PD animal model. Further, EPL-beta CD enhanced this protective effects, suggesting a novel therapeutic approach to ameliorate the symptoms of PD. (AU)

• Processo FAPESP: 15/20785-8 - Bioprospecção de produtos de origem natural com potencial atividade neuroprotetora em modelos animais de epilepsia e doença de Parkinson.
• Beneficiário: Alessandra Mussi Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/03354-3 - Mecanismos fisiopatológicos e intervenções neuroprotetoras em um modelo animal progressivo de doença de parkinson
• Beneficiário: Regina Helena da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular