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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Eplingiella fruticosa leaf essential oil complexed with beta-cyclodextrin produces a superior neuroprotective and behavioral profile in a mice model of Parkinson's disease

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Author(s):
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Beserra-Filho, Jose I. A. [1] ; de Macedo, Amanda M. [1] ; Leao, Anderson H. F. F. [2] ; Bispo, Jose Marcos M. [3] ; Santos, Jose R. [3] ; de Oliveira-Melo, Allan John [4] ; Menezes, Paula dos Passos [4] ; Duarte, Marcelo C. [4] ; de Souza Araujo, Adriano A. [4] ; Silva, Regina H. [2] ; Quintans-Junior, Lucindo J. [4] ; Ribeiro, Alessandra M. [1]
Total Authors: 12
Affiliation:
[1] Univ Fed Sao Paulo, Dept Biosci, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Pharmacol, Edificio Jose Leal Prado, Rua Botucatu 862, BR-04023062 Sao Paulo, SP - Brazil
[3] Univ Fed Sergipe, Dept Biosci, Ave Ver Olimpio Grande S-N, BR-49500000 Itabaiana, SE - Brazil
[4] Univ Fed Sergipe, Dept Physiol, Ave Marechal Rondon S-N, BR-49100000 Aracaju, SE - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Food and Chemical Toxicology; v. 124, p. 17-29, FEB 2019.
Web of Science Citations: 1
Abstract

Evidence indicates that oxidative stress has an important role in the onset and progression of Parkinson's disease (PD). Antioxidant agents from natural products have shown neuroprotective effects in animal models of PD. Eplingiella fruticosa is an aromatic and medicinal plant of the Lamiaceae family that include culinary herbs. The essential oil (EPL) has anti-inflammatory and antioxidant activities. Cyclodextrins are used to enhances pharmacological profile of essential oil. We obtained the EPL from leaves and complexed with beta-cyclodextrin (EPL-beta CD). Phytochemical analysis showed as main constituents: beta-caryophyllene, bicyclogermacrene and 1,8-cineole. We evaluated the effects of EPL and EPL-beta CD (5 mg/kg, p.o. for 40 days) on male mice submitted to the progressive reserpine PD model. Behavioral evaluations, lipid peroxidation quantification and immunohistochemistry for tyrosine hydroxylase were conducted. EPL delayed the onset of catalepsy and decreased membrane lipid peroxides levels in the striatum. EPL-beta CD also delayed the onset of catalepsy, reduced the frequency of oral diskynesia, restored memory deficit, produced anxiolytic activity and protected against dopaminergic depletion in the striatum and SNpc. These findings showed that EPL has a potential neuroprotective effect in a progressive PD animal model. Further, EPL-beta CD enhanced this protective effects, suggesting a novel therapeutic approach to ameliorate the symptoms of PD. (AU)

FAPESP's process: 15/20785-8 - Bioprospecting of natural products with potential neuroprotective activity in animal models of Epilepsy and Parkinson's disease.
Grantee:Alessandra Mussi Ribeiro
Support Opportunities: Regular Research Grants
FAPESP's process: 15/03354-3 - PATHOPHYSIOLOGICAL MECHANISMS AND NEUROPROTECTIVE INTERVENTIONS IN A PROGRESSIVE ANIMAL MODEL OF PARKINSON'S DISEASE
Grantee:Regina Helena da Silva
Support Opportunities: Regular Research Grants