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Bioprospecting of natural products with potential neuroprotective activity in animal models of Epilepsy and Parkinson's disease

Grant number: 15/20785-8
Support type:Regular Research Grants
Duration: October 01, 2016 - December 31, 2018
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal Investigator:Alessandra Mussi Ribeiro
Grantee:Alessandra Mussi Ribeiro
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil


Studies have shown that compounds from natural products, such as plant extracts or arthropods venoms are potential antioxidants, anxiolytics, anticonvulsants and antidepressants agents. Compounds from extracts are true "chemical weapons" which have different pharmacological effects on various biological systems. For instance, many of these natural products are neurotoxins with specificity and affinity for nervous tissue. These can act on receptors and transporters, or they targeted selectively on ligand- or voltage-dependent ion channels present in the neuronal membrane of invertebrates and vertebrates. Natural products are tools that can help in the understanding of neuropathological alterations in neurotransmission in humans, relating to diseases such as epilepsy, Parkinson's disease, ischemia, glaucoma, etc. Nevertheless, the potential clinical use of isolated components from natural products is poorly exploited. From another standpoint, new isolation techniques, purification and synthesis of natural products can provide a new generation of bioactive substances that could be available as feasible tools in scientific research, and especially for the development of new therapies. The development of therapeutics for neuropathologies is undoubted, further the challenge search the knowledge in neuroscience and understanding of brain diseases, which can occur with use of new bioactive toxins. The aim of the present study is to investigate the effects of the extract of the Hyptis fruticosa and Lippia grata plants, and Dinoponera quadriceps ant venom in animal models of epilepsy and Parkinson's disease. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BESERRA-FILHO, JOSE I. A.; DE MACEDO, AMANDA M.; LEAO, ANDERSON H. F. F.; BISPO, JOSE MARCOS M.; SANTOS, JOSE R.; DE OLIVEIRA-MELO, ALLAN JOHN; MENEZES, PAULA DOS PASSOS; DUARTE, MARCELO C.; DE SOUZA ARAUJO, ADRIANO A.; SILVA, REGINA H.; QUINTANS-JUNIOR, LUCINDO J.; RIBEIRO, ALESSANDRA M. Eplingiella fruticosa leaf essential oil complexed with beta-cyclodextrin produces a superior neuroprotective and behavioral profile in a mice model of Parkinson's disease. Food and Chemical Toxicology, v. 124, p. 17-29, FEB 2019. Web of Science Citations: 1.
MEDEIROS, KATTY ANNE A. L.; DOS SANTOS, JOSE R.; MELO, THAIS CRISTINA DE S.; DE SOUZA, MARINA F.; SANTOS, LUCIANO DE G.; DE GOIS, AUDERLAN M.; CINTRA, RACHEL R.; LINS, LIVIA CRISTINA R. F.; RIBEIRO, ALESSANDRA M.; MARCHIORO, MURILO. Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra. BIOMEDICAL JOURNAL, v. 41, n. 5, p. 298-305, OCT 2018. Web of Science Citations: 2.
LINS, LIVIA CRISTINA R. F.; SOUZA, MARINA F.; BISPO, JOSE MARCOS M.; GOIS, AUDERLAN M.; MELO, THAIS CRISTINA S.; ANDRADE, RAYR ANTONIO S.; QUINTANS-JUNIOR, LUCINDO J.; RIBEIRO, ALESSANDRA M.; SILVA, REGINA H.; SANTOS, JOSE R.; MARCHIORO, MURILO. Carvacrol prevents impairments in motor and neurochemical parameters in a model of progressive parkinsonism induced by reserpine. Brain Research Bulletin, v. 139, p. 9-15, MAY 2018. Web of Science Citations: 6.

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