Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines

Autor(es)

da Silva, Allan Ribeiro ^[1] ; dos Santos, Deborah Araujo ^{[1, 2]} ; Paixao, Marcio Weber ^[1] ; Correa, Arlene Goncalves ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Ctr Excellence Res Sustainable Chem, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Chem, BR-13563120 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Molecules; v. 24, n. 3 FEB 1 2019.
• Citações Web of Science: 3

Resumo

Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines to the preparation of other heterocycles are discussed emphasizing the stereoselectivity of the reactions. (AU)

• Processo FAPESP: 17/23867-0 - Síntese organocatalisada de aziridina aldeídos e aplicações em reações multicomponentes
• Beneficiário: Allan Ribeiro da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/09961-7 - Planejamento, Síntese e Atividade Tripanossomicida de Inibidores Covalentes Reversíveis da Enzima Cruzaína
• Beneficiário: Deborah Araujo dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia