| Full text | |
| Author(s): |
da Silva, Allan Ribeiro
[1]
;
dos Santos, Deborah Araujo
[1, 2]
;
Paixao, Marcio Weber
[1]
;
Correa, Arlene Goncalves
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Fed Sao Carlos, Ctr Excellence Res Sustainable Chem, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Chem, BR-13563120 Sao Carlos, SP - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | Molecules; v. 24, n. 3 FEB 1 2019. |
| Web of Science Citations: | 3 |
| Abstract | |
Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines to the preparation of other heterocycles are discussed emphasizing the stereoselectivity of the reactions. (AU) | |
| FAPESP's process: | 17/23867-0 - Organocatalyzed synthesis of aziridine aldehydes and applications in multicomponent reactions |
| Grantee: | Allan Ribeiro da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/09961-7 - Molecular Design, Synthesis, and Trypanocidal Activity of Reversible Covalent Inhibitors of Cruzain Enzyme |
| Grantee: | Deborah Araujo dos Santos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock |
| Grantee: | Arlene Gonçalves Corrêa |
| Support Opportunities: | Research Grants - Research Centers in Engineering Program |