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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines

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da Silva, Allan Ribeiro [1] ; dos Santos, Deborah Araujo [1, 2] ; Paixao, Marcio Weber [1] ; Correa, Arlene Goncalves [1]
Total Authors: 4
[1] Univ Fed Sao Carlos, Ctr Excellence Res Sustainable Chem, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Chem, BR-13563120 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Molecules; v. 24, n. 3 FEB 1 2019.
Web of Science Citations: 3

Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines to the preparation of other heterocycles are discussed emphasizing the stereoselectivity of the reactions. (AU)

FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support type: Research Grants - Research Centers in Engineering Program
FAPESP's process: 18/09961-7 - Molecular design, synthesis, and trypanocidal activity of reversible covalent inhibitors of cruzain enzyme
Grantee:Deborah Araujo dos Santos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/23867-0 - Organocatalyzed synthesis of aziridine aldehydes and applications in multicomponent reactions
Grantee:Allan Ribeiro da Silva
Support type: Scholarships in Brazil - Post-Doctorate