Biocompatibility of mineral trioxide aggregate flow and biodentine

Autor(es)

Mondelli, J. A. S. ^[1] ; Hoshino, R. A. ^[2] ; Weckwerth, P. H. ^[1] ; Cerri, P. S. ^[3] ; Leonardo, R. T. ^[2] ; Guerreiro-Tanomaru, J. M. ^[2] ; Tanomaru-Filho, M. ^[2] ; da Silva, G. F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sagrado Coracao, Prorectory Res & Postgrad, Bauru, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Araraquara Dent Sch, Dept Restorat Dent, Araraquara, SP - Brazil

^[3] UNESP Sao Paulo State Univ, Araraquara Dent Sch, Dept Morphol, Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Endodontic Journal; v. 52, n. 2, p. 193-200, FEB 2019.
• Citações Web of Science: 2

Resumo

AimTo evaluate the influence of powder-to-gel ratio (0.19g powder to 50L of gel, thick MTA Flow, and 0.06g powder to 50L of gel, fluid MTA Flow) on biocompatibility of MTA Flow (Ultradent Products Inc., South Jordan, UT, USA, lot: 2015122901) and compare it with Biodentine (Septodont Inc., Saint-Maur-des-Fosses, France, lot: B18542A). MethodologyThe materials were manipulated and inserted into polyethylene tubes for implantation in twenty rats. After 7, 15, 30 and 60days, the specimens were removed and embedded in paraffin. Haematoxylin and eosin sections were used to count the number of inflammatory cells (IC) and fibroblastsmm(-2) (Fb). In the Masson's trichrome-stained sections, the fibrous capsule thickness was measured; picrosirius red-stained sections were used for birefringent collagen quantification. The data were submitted to two-way ANOVA and Tukey test (P0.05). ResultsA significantly lower number of IC and consequently higher number of Fb were observed in the capsules adjacent to thick MTA Flow at all periods, in comparison with other materials (P0.05). At 60days, the quantity of birefringent collagen was significantly greater in the tissue in contact with thick MTA Flow, when compared with fluid MTA Flow and Biodentine. ConclusionsAlthough thick MTA Flow induced a less intense inflammatory response, all evaluated materials are biocompatible because they allowed regression of this process after 60days. (AU)

• Processo FAPESP: 16/20637-1 - Avaliação da reação tecidual provocada pelo MTA flow em duas proporções distintas após implantação no subcutâneo de ratos
• Beneficiário: Joelma Aparecida da Silva Mondelli
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica