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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of chronic kidney disease in ischemic cardiomyopathy Long-term follow-up-REVISION-DM2 trial

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Autor(es):
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Hueb, Thiago Ovanessian [1] ; Lima, Eduardo Gomes [1] ; Rocha, Mauricio S. [1] ; Siqueira, Sergio F. [1] ; Dorio Nishioka, Silvana Angelina [1] ; Peixoto, Giselle L. [1] ; Saccab, Marcos M. [1] ; Rahmi Garcia, Rosa Maria [1] ; Ramires, Jose Antonio F. [1] ; Kalil Filho, Roberto [1] ; Martinelli Filho, Martino [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Div Clin Cardiol, Heart Inst InCor, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: MEDICINE; v. 98, n. 12 MAR 2019.
Citações Web of Science: 0
Resumo

A strong association exists between chronic kidney disease (CKD) and coronary artery disease (CAD). The role of CKD in the long-term prognosis of CAD patients with versus those without CKD is unknown. This study investigated whether CKD affects ventricular function. From January 2009 to January 2010, 918 consecutive patients were selected from an outpatient database. Patients had undergone percutaneous, surgical, or clinical treatment and were followed until May 2015. In patients with preserved renal function (n = 405), 73 events (18%) occurred, but 108 events (21.1%) occurred among those with CKD (n = 513) (P < .001). Regarding left ventricular ejection fraction (LVEF) <50%, we found 84 events (21.5%) in CKD patients and 12 (11.8%) in those with preserved renal function (P < .001). The presence of LVEF <50% brought about a modification effect. Death occurred in 22 (5.4%) patients with preserved renal function and in 73 (14.2%) with CKD (P < .001). In subjects with LVEF <50%, 66 deaths (16.9%) occurred in CKD patients and 7 (6.9%) in those with preserved renal function (P = .001). No differences were found in CKD strata regarding events or overall death among those with preserved LVEF. In a multivariate model, creatinine clearance remained an independent predictor of death (P < .001). We found no deleterious effects of CKD in patients with CAD when ventricular function was preserved. However, there was a worse prognosis in patients with CKD and ventricular dysfunction. Resgistry number is ISRCTN17786790 at . (AU)

Processo FAPESP: 11/08278-2 - Revision: registro de disfunção ventricular isquêmica
Beneficiário:Martino Martinelli Filho
Modalidade de apoio: Auxílio à Pesquisa - Regular