Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of chronic kidney disease in ischemic cardiomyopathy Long-term follow-up-REVISION-DM2 trial

Full text
Author(s):
Show less -
Hueb, Thiago Ovanessian [1] ; Lima, Eduardo Gomes [1] ; Rocha, Mauricio S. [1] ; Siqueira, Sergio F. [1] ; Dorio Nishioka, Silvana Angelina [1] ; Peixoto, Giselle L. [1] ; Saccab, Marcos M. [1] ; Rahmi Garcia, Rosa Maria [1] ; Ramires, Jose Antonio F. [1] ; Kalil Filho, Roberto [1] ; Martinelli Filho, Martino [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Sch Med, Div Clin Cardiol, Heart Inst InCor, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: MEDICINE; v. 98, n. 12 MAR 2019.
Web of Science Citations: 0
Abstract

A strong association exists between chronic kidney disease (CKD) and coronary artery disease (CAD). The role of CKD in the long-term prognosis of CAD patients with versus those without CKD is unknown. This study investigated whether CKD affects ventricular function. From January 2009 to January 2010, 918 consecutive patients were selected from an outpatient database. Patients had undergone percutaneous, surgical, or clinical treatment and were followed until May 2015. In patients with preserved renal function (n = 405), 73 events (18%) occurred, but 108 events (21.1%) occurred among those with CKD (n = 513) (P < .001). Regarding left ventricular ejection fraction (LVEF) <50%, we found 84 events (21.5%) in CKD patients and 12 (11.8%) in those with preserved renal function (P < .001). The presence of LVEF <50% brought about a modification effect. Death occurred in 22 (5.4%) patients with preserved renal function and in 73 (14.2%) with CKD (P < .001). In subjects with LVEF <50%, 66 deaths (16.9%) occurred in CKD patients and 7 (6.9%) in those with preserved renal function (P = .001). No differences were found in CKD strata regarding events or overall death among those with preserved LVEF. In a multivariate model, creatinine clearance remained an independent predictor of death (P < .001). We found no deleterious effects of CKD in patients with CAD when ventricular function was preserved. However, there was a worse prognosis in patients with CKD and ventricular dysfunction. Resgistry number is ISRCTN17786790 at . (AU)

FAPESP's process: 11/08278-2 - Revision: registry of ischemic ventricular dysfunction
Grantee:Martino Martinelli Filho
Support Opportunities: Regular Research Grants