Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach

Autor(es):Mostrar menos -

Gaspar, Rafael Calais ^[1] ; Veiga, Camilla Bertuzzo ^{[2, 3]} ; Bessi, Mariana Pereira ^{[2, 3]} ; Datilo, Marcella Neves ^{[2, 3]} ; Sant'Ana, Marcella Ramos ^{[2, 3]} ; Rodrigues, Patricia Brito ^{[2, 3]} ; de Moura, Leandro Pereira ^[1] ; Ramos da Silva, Adelino Sanchez ^[4] ; Santos, Gustavo Aparecido ^[5] ; Catharino, Rodrigo Ramos ^[5] ; Ropelle, Eduardo Rochete ^[1] ; Pauli, Jose Rodrigo ^[1] ; Cintra, Dennys Esper ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Appl Sci, LabMEx, Lab Mol Biol Exercise, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Sch Appl Sci, LabGeN, Nutr Genom Lab, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Sch Appl Sci, CELN, Nutrigen & Lipids Res Ctr, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Sao Paulo - Brazil

^[5] Univ Estadual Campinas, Innovare, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 66, p. 52-62, APR 2019.
• Citações Web of Science: 1

Resumo

GPR120 and GPR40 were recently reported as omega-3 (omega 3) receptors with anti-inflammatory properties. Physical exercise could increase the expression of these receptors in the liver, improving hepatic metabolism in obesity and type 2 diabetes. Our aim was to investigate GPR120/40 in the liver of lean and obese mice after acute or chronic physical exercise, with or without the supplementation of omega 3 rich flaxseed oil (FS), as well as assess the impact of exercise and FS on insulin signaling and inflammation. Mice were fed a high-fat diet (HF) for 4 weeks to induce obesity and subsequently subjected to exercise with or without FS, or FS alone. Insulin signaling, inflammatory markers and GPR120/40 and related cascades were measured. Chronic, but not acute, exercise and FS increased GPR120, but not GPR40, activating beta-arrestin-2 and decreasing the inflammatory response, as well as reducing fat depots in liver and adipose tissue. Exercise or a source of omega 3 led to a higher tolerance to fatigue and an increased running distance and speed. The combination of physical exercise and omega 3 food sources could provide a new strategy against obesity through the modulation of hepatic GPR120 and an increase in exercise performance. (C) 2018 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 14/15258-6 - Modulação da expressão hepática do receptor GPR120 mediada por exercício físico em roedores obesos
• Beneficiário: Guilherme Pedron Formigari
• Modalidade de apoio: Bolsas no Brasil - Mestrado