| Full text | |
| Author(s): Show less - |
Gaspar, Rafael Calais
[1]
;
Veiga, Camilla Bertuzzo
[2, 3]
;
Bessi, Mariana Pereira
[2, 3]
;
Datilo, Marcella Neves
[2, 3]
;
Sant'Ana, Marcella Ramos
[2, 3]
;
Rodrigues, Patricia Brito
[2, 3]
;
de Moura, Leandro Pereira
[1]
;
Ramos da Silva, Adelino Sanchez
[4]
;
Santos, Gustavo Aparecido
[5]
;
Catharino, Rodrigo Ramos
[5]
;
Ropelle, Eduardo Rochete
[1]
;
Pauli, Jose Rodrigo
[1]
;
Cintra, Dennys Esper
[2, 3]
Total Authors: 13
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Appl Sci, LabMEx, Lab Mol Biol Exercise, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, LabGeN, Nutr Genom Lab, Sao Paulo - Brazil
[3] Univ Estadual Campinas, Sch Appl Sci, CELN, Nutrigen & Lipids Res Ctr, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Sao Paulo - Brazil
[5] Univ Estadual Campinas, Innovare, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 66, p. 52-62, APR 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
GPR120 and GPR40 were recently reported as omega-3 (omega 3) receptors with anti-inflammatory properties. Physical exercise could increase the expression of these receptors in the liver, improving hepatic metabolism in obesity and type 2 diabetes. Our aim was to investigate GPR120/40 in the liver of lean and obese mice after acute or chronic physical exercise, with or without the supplementation of omega 3 rich flaxseed oil (FS), as well as assess the impact of exercise and FS on insulin signaling and inflammation. Mice were fed a high-fat diet (HF) for 4 weeks to induce obesity and subsequently subjected to exercise with or without FS, or FS alone. Insulin signaling, inflammatory markers and GPR120/40 and related cascades were measured. Chronic, but not acute, exercise and FS increased GPR120, but not GPR40, activating beta-arrestin-2 and decreasing the inflammatory response, as well as reducing fat depots in liver and adipose tissue. Exercise or a source of omega 3 led to a higher tolerance to fatigue and an increased running distance and speed. The combination of physical exercise and omega 3 food sources could provide a new strategy against obesity through the modulation of hepatic GPR120 and an increase in exercise performance. (C) 2018 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 14/15258-6 - Modulation of hepatic expression of GPR120 receptor mediated physical exercise in obese rodents |
| Grantee: | Guilherme Pedron Formigari |
| Support Opportunities: | Scholarships in Brazil - Master |