Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review

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Santos, Rafael Silva ^{[1, 2]} ; Loureiro, Kahynna Cavalcante ^{[1, 2]} ; Rezende, Polyana Santos ^{[1, 2]} ; Andrade, Luciana Nalone ^{[1, 2]} ; Barbosa, Raquel de Melo ^[3] ; Santini, Antonello ^[4] ; Santos, Ana Claudia ^{[5, 6]} ; da Silva, Classius Ferreira ^[7] ; Souto, Eliana Barbosa ^{[5, 8]} ; de Sousa, Damiao Pergentino ^[9] ; Amaral, Ricardo Guimaraes ^[10] ; Severino, Patricia ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Tiradentes UNIT, Aracaju - Brazil

^[2] Inst Tecnol & Pesquisa, Lab Nanotecnol & Nanomed LNMed, Ave Murilo Dantas, Aracaju - Brazil

^[3] Univ Fed Rio Grande do Norte, Fac Pharm, Dept Pharm, Petropolis - Brazil

^[4] Univ Napoli Federico II, Dept Pharm, Naples - Italy

^[5] Univ Coimbra FFUC Polo Ciencias Saude Azinhaga Sa, Fac Pharm, Dept Pharmaceut Technol, Coimbra - Portugal

^[6] Inst Mol & Cell Biol, Inst Innovat & Hlth Res, Grp Genet Cognit Dysfunct, Porto - Portugal

^[7] Univ Fed Sao Paulo, Biotechnol Lab Nat Prod BIONAT, Inst Environm Sci Chem & Pharmaceut, Diadema - Brazil

^[8] Univ Coimbra, Fac Pharm, REQUIMTE LAQV Grp Pharmaceut Technol, Coimbra - Portugal

^[9] Univ Fed Paraiba, Dept Ciencias Farm, Joao Pessoa, Paraiba - Brazil

^[10] Univ Fed Sergipe, Dept Fisiol, Sao Cristovao - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF DERMATOLOGICAL TREATMENT; v. 30, n. 6 APR 2019.
• Citações Web of Science: 1

Resumo

Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery, overcoming the problems of low bioavailability and high toxicity of these drugs. Due to their unique features, namely the small mean particle size, nanoparticles contribute to the enhanced drug absorption and uptake by the target cells, potentiating the therapeutic drug effect. The topical route is desirable due to the adverse effects arising from oral administration. This review provides a comprehensive analysis of the use of nano compounds for the current treatment of topical fungal infections. A special emphasis is given to the employment of lipid nanoparticles, due to their recognized efficacy, versatility, and biocompatibility, attracting the major attention as novel topical nanocompounds used for the administration of antifungal drugs. (AU)

• Processo FAPESP: 08/00421-8 - Incorporação e avaliação imunológica de antigenos tumorais incorporados em nanopartículas lipídicas sólidas e nanocarreadores lipídicos sólidos
• Beneficiário: Patricia Severino
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/20801-2 - Encapsulação de polimixina B em NLS para incorporação em hidrogéis mucoadesivos para tratamento de mucosite oral
• Beneficiário: Patricia Severino
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado