Age and leptinemia association with anxiety and depression symptoms in overweight middle-aged women

Autor(es)

Naufel, Maria Fernanda ^[1] ; Boldarine, Valter Tadeu ^[1] ; Oyama, Lila Missae ^[1] ; Oller do Nascimento, Claudia Maria ^[1] ; Silva dos Santos, Gianni Mara ^[2] ; Hachul, Helena ^{[3, 4]} ; Ribeiro, Eliane Beraldi ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Appl Stat, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo, SP - Brazil

^[4] Univ Fed Sao Paulo UNIFESP, Dept Gynecol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY; v. 26, n. 3, p. 317-324, MAR 2019.
• Citações Web of Science: 1

Resumo

Objective: The aim of the study was to investigate the effect of menopause and of postmenopausal stages on depression and anxiety symptoms, and whether these symptoms associate with anthropometric, metabolic, and hormonal parameters in midlife women. Methods: Postmenopausal women (age 50-65), either at early (EPM, n = 33) or late (LPM, n = 23) postmenopause, and 23 premenopausal controls (PreM, age 40-50), matched for BMI with the PM groups, were studied. Blood biochemical and hormonal determinations, bioimpedance anthropometry, and depression and anxiety symptoms (Beck's depression {[}BDI] and anxiety {[}BAI] inventories) were conducted. Results: The BAI score was higher in both PM groups than in the PreM group. In contrast, only the LPM group showed a significantly elevated BDI score. All groups presented overweight and abdominal obesity, having similar BMI and waist/hip ratio values. Both PM groups showed insulin resistance, whereas only the LPM group presented decreased skeletal muscle mass and basal metabolic rate. Correlation analysis, including all 79 middle-aged women, showed age, percentage body fat, waist/hip ratio, and leptinemia to correlate positively with the anxiety and depression scores. Multivariate regression showed leptin and age to associate positively with depressive-and anxious-like symptoms. Conclusions: Postmenopausal women presented impaired body composition, energy expenditure, insulin sensitivity, and mental symptoms, in comparison to similarly overweight premenopausal women. Among all the overweight midlife women, these symptoms were more strongly associated with age and leptin levels than with reproductive aging itself. The data indicate that, among overweight middle-aged women with abdominal obesity, the aging process and the development of leptin resistance are associated with impairment of mental health. (AU)

• Processo FAPESP: 12/03172-4 - Obesidade e depressão na pós-menopausa: estudo em ratas dos efeitos da ovariectomia sobre aspectos comportamentais e da regulação central da ingestão alimentar
• Beneficiário: Eliane Beraldi Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular