Hierarchical assessment of host factors influencing the spontaneous resolution of hepatitis C infection

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Scarin Provazzi, Paola Jocelan ^[1] ; Goncalves Rossi, Livia Maria ^[1] ; Carneiro, Bruno Moreira ^[1] ; Miura, Valeria Chamas ^[1] ; Rodrigues Rosa, Plinio Cesar ^[1] ; de Carvalho, Lucas Rodrigues ^[1] ; Queiroz de Andrade, Stephane Tereza ^[1] ; Fachini, Roberta Maria ^[2] ; Tommasini Grotto, Rejane Maria ^[3] ; Silva, Giovanni Faria ^[3] ; Valencio, Carlos Roberto ^[4] ; Neto, Paulo Scarpelini ^[4] ; Cordeiro, Jose Antonio ^[4] ; Nogueira, Mauricio Lacerda ^[5] ; Rahal, Paula ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[2] Sao Jose Do Rio Preto Med Sch, Dept Hepatol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Sao Paulo State Univ, Dept Internal Med, UNESP, BR-18618970 Botucatu, SP - Brazil

^[4] Sao Paulo State Univ, UNESP, Dept Comp Sci & Stat, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[5] Sao Jose Do Rio Preto Med Sch, Lab Virol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Microbiology; v. 50, n. 1, p. 147-155, JAN 2019.
• Citações Web of Science: 1

Resumo

BackgroundHepatitis C virus (HCV) infection is associated with chronic liver disease, resulting in cirrhosis and hepatocellular carcinoma. Approximately 20% of HCV infections are spontaneously resolved. Here, we assessed the hierarchical relevance of host factors contributing to viral clearance.MethodsDNA samples from 40 resolved infections and 40 chronic HCV patients paired by age were analyzed. Bivariate analysis was performed to rank the importance of each contributing factor in spontaneous HCV clearance.ResultsInterestingly, 63.6% of patients with resolved infections exhibited the protective genotype CC for SNP rs12979860. Additionally, 59.3% of patients with resolved infections displayed the protective genotype TT/TT for SNP ss469415590. Moreover, a ranking of clearance factors was estimated. In order of importance, the IL28B CC genotype (OR 0.197, 95% CI 0.072-0.541) followed by the INFL4 TT/TT genotype (OR 0.237, 95% CI 0.083-0.679), and female gender (OR 0.394, 95% CI 0.159-0.977) were the main predictors for clearance of HCV infection.ConclusionsHCV clearance is multifactorial and the contributing factors display a hierarchical order. Identifying all elements playing role in HCV clearance is of the most importance for HCV-related disease management. Dissecting the relevance of each contributing factor will certainly improve our understanding of the pathogenesis of HCV infection. (AU)

• Processo FAPESP: 14/22198-0 - Potencial terapêutico de fármacos flavonóidicos na infecção com o vírus da hepatite C
• Beneficiário: Paula Rahal
• Modalidade de apoio: Auxílio à Pesquisa - Regular