Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, in the Oral Cavity

Autor(es)

dos Santos Costa, Sara Ferreira ^[1] ; Barbosa Silva, Andre Myller ^[1] ; Amaral-Silva, Gleyson Kleber ^[2] ; Rebelo Pontes, Helder Antonio ^[3] ; Correa Pontes, Flavia Sirotheau ^[3] ; Fonseca, Felipe Paiva ^[1] ; de Almeida, Oslei Paes ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG - Brazil

^[2] Univ Estadual Campinas, Dept Oral Diag, Piracicaba Dent Sch, Piracicaba - Brazil

^[3] Fed Univ Para, Joao de Barros Barreto Univ Hosp, Belem, Para - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CRANIOFACIAL SURGERY; v. 30, n. 3, p. E259-E262, MAY 2019.
• Citações Web of Science: 0

Resumo

Lymphomas of the oral cavity are rare and the most frequent type is diffuse large B-cell lymphoma (DLBCL). EpsteinBarr virus (EBV) is known to be associated with the development of different lymphomas. In 2008, the World Health Organization provisionally included the EBV-positive DLBCL of the elderly in the classification of hematopoietic and lymphoid tumors as a lymphoma occurring in older individuals without any known immunodeficiency. However, it has since been recognized that this entity may occur in younger individuals and present similar clinical parameters in both age groups. As a result, the 2017 revision has declined the term elderly and modified it to EBV-positive DLBCL, not otherwise specified (NOS). In this report, we describe a rare case of EBV-positive DLBCL, NOS, presenting as a painless swelling in the oral cavity. This entity shows a more aggressive clinical course than EBV-negative DLBCL, and other lymphoproliferative disorders should be considered in the differential diagnosis. (AU)

• Processo FAPESP: 17/14880-3 - Análise clinicopatológica e imunoistoquímica das hiperplasias linfoides foliculares e dos linfomas da cavidade oral
• Beneficiário: Oslei Paes de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular