Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil

Texto completo
Autor(es):
Balmant, Nathalie Vieira [1, 2] ; Reis, Rejane de Souza [3] ; Santos, Marceli de Oliveira [4] ; Maschietto, Mariana [5] ; de Camargo, Beatriz [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Inst Nacl Canc, Rio De Janeiro, RJ - Brazil
[2] Inst Nacl Canc, Ctr Pesquisa, Rio De Janeiro, RJ - Brazil
[3] Fundacao Canc, Rio De Janeiro, RJ - Brazil
[4] Inst Nacl Canc, Coordenacao Prevencao & Vigilancia, Rio De Janeiro, RJ - Brazil
[5] Ctr Nacl Pesquisa Energia & Mat, Lab Nacl Biociencias, Campinas, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Clinics; v. 74, 2019.
Citações Web of Science: 0
Resumo

OBJECTIVES: Bone cancers occur frequently in children, adolescents, and young adults aging 15 to 29 years. Osteosarcoma and Ewing sarcoma are the most frequent subtypes in this population. The aim of this study was to describe incidence and mortality trends of bone cancers among Brazilian children, adolescents and young adults. METHODS: Incidence information was obtained from 23 population-based cancer registries. Mortality data were extracted from the Atlas of Cancer Mortality from 1979 to 2013. Specific and adjusted rates per million were analyzed according to gender, morphology and age at diagnosis. Median rates were used as a measure of central tendency. Joinpoint regression was applied to analyze trends. RESULTS: Median incidence rates were 5.74 and 11.25 cases per million in children and young adults respectively. Osteosarcoma in the 15-19 years aged group had the highest incidence rates. Stable incidence rates were observed among five registries in 0-14 year's age group. Four registries had a decreased incidence trend among adolescents and young adults. Median mortality rates were 1.22 and 5.07 deaths per million in children and young adults respectively. Increased mortality was observed on the North and Northeast regions. Decreased mortality trends were seen in the South (children) and Southeast (adolescents and young adults). CONCLUSION: Osteosarcoma and Ewing Sarcoma are the most incident bone cancers in all Brazilian regions. Bone cancers showed incidence and mortality patterns variation within the geographic regions and across age groups, although not significant. Despite limitations, it is crucial to monitor cancer epidemiology trends across geographic Brazilian regions. (AU)

Processo FAPESP: 15/06281-7 - Investigação da regulação epigenética em tumores sólidos pediátricos
Beneficiário:Mariana Camargo Maschietto
Linha de fomento: Bolsas no Brasil - Apoio a Jovens Pesquisadores