Development of Secondary Microcephaly After Delivery: Possible Consequence of Mother-Baby Transmission of Zika Virus in Breast Milk

Autor(es):Mostrar menos -

Mello, Alexandra Siqueira ^[1] ; Pascalicchio Bertozzi, Ana Paula A. ^[2] ; Rodrigues, Maria Manoela D. ^[2] ; Gazeta, Rosa Estela ^[2] ; Moron, Antonio F. ^{[3, 4]} ; Soriano-Arandes, Antoni ^[5] ; Pereira Sarmento, Stephanno Gomes ^{[3, 4]} ; Vedovello, Danila ^[1] ; Silva, Andrea Cristina B. ^[1] ; Grillo Fajardo, Thamirys C. ^[1] ; Witkin, Steven S. ^[6] ; Passos, Saulo D. ^{[1, 2]} ; Consortium, Cohort Zika Jundiai

Afiliação do(s) autor(es)

^[1] Jundiai Sch Med, Dept Pediat, Lab Pediat Infectol, Sao Paulo, SP - Brazil

^[2] Dept Pediat, Sao Paulo, SP - Brazil

^[3] Fed Univ Sao Paulo UNIFESP, Paulista Sch Med, Dept Obstet, Sao Paulo, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Paulista Ctr Fetal Medidne, Sao Paulo, SP - Brazil

^[5] Hosp Univ Vall dHebron, Paediat Infect Dis & Immunodeficiencies Unit, Barcelona - Spain

^[6] Weill Cornell Med, Dept Obstet & Gynecol, New York, NY - USA

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF CASE REPORTS; v. 20, p. 723-725, MAY 21 2019.
• Citações Web of Science: 0

Resumo

Objective: Unusual clinical course Background: The Zika virus is an arbovirus that has as main source of transmission the bite of infected insects of the genus Aedes and has been associated with cases of congenital malformation and microcephaly in neonates. However, other sources of transmission have been identified since the emergence of this virus in the world population, such as vertical transmission by semen and possibly other body fluids such as vaginal secretion and breast milk. Case Report: An infant, born to a mother whose previous delivery was a baby with severe microcephaly, was normal and was negative for Zika virus at birth but developed secondary microcephaly 1 month later, that persisted. The baby was exclusively breast-fed and Zika virus was present in the mother's milk. Conclusions: We report the detection of Zika virus exclusively in the breast milk of a woman after her second delivery of an infant, who later developed microcephaly. This case is consistent with possible vertical transmission. (AU)

• Processo FAPESP: 16/08578-0 - Infecção vertical pelo vírus Zika e suas repercussões na área materno-infantil
• Beneficiário: Saulo Duarte Passos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/22007-8 - Infecção vertical pelo vírus Zika e suas repercussões na área materno-infantil
• Beneficiário: Danila Vedovello de Jesus
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado