Modified-release topical hydrogels: a ten-year review

Autor(es)

Croisfelt, Fernanda Machado ^[1] ; Tundisi, Louise Lacalendola ^[2] ; Ataide, Janaina Artem ^[2] ; Silveira, Edgar ^[3] ; Tambourgi, Elias Basile ^[4] ; Jozala, Angela Faustino ^[5] ; Barbosa Souto, Eliana Maria ^{[6, 7]} ; Mazzola, Priscila Gava ^[2]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Inst Biol, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Fac Pharmaceut Sci, Candido Portinari St, 200, Cidade Univ, BR-13083871 Campinas, SP - Brazil

^[3] Fed Univ Uberlandia UFU, Genet & Biochem Inst, Uberlandia, MG - Brazil

^[4] Univ Campinas UNICAMP, Sch Chem Engn, Campinas, SP - Brazil

^[5] Univ Sorocaba UNISO, LAMINFE Lab Ind Microbiol & Fermentat Proc, Sorocaba - Brazil

^[6] Univ Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra - Portugal

^[7] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga - Portugal

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Materials Science; v. 54, n. 16, p. 10963-10983, AUG 2019.
• Citações Web of Science: 1

Resumo

Hydrogels are polymeric networks with tridimensional structure, which are able to load water and other substances. Such property makes hydrogels suitable for innumerous applications in biomedical field. Hydrogels are being used as raw materials in pharmaceutical formulations for more than 60years, while significant progress is very well documented in topical use. Natural and synthetic polymers have been applied to develop smart hydrogels that respond to physiological stimuli to follow the release of the loaded bioactive ingredient. This paper discusses the most relevant polymers commonly used in pharmaceutical formulations for modified topical delivery. (AU)

• Processo FAPESP: 16/03444-5 - Desenvolvimento de formulação farmacêutica cicatrizante contendo bromelina extraída de resíduos industriais
• Beneficiário: Priscila Gava Mazzola
• Linha de fomento: Auxílio à Pesquisa - Regular