Modified-release topical hydrogels: a ten-year review

Author(s)

Croisfelt, Fernanda Machado ^[1] ; Tundisi, Louise Lacalendola ^[2] ; Ataide, Janaina Artem ^[2] ; Silveira, Edgar ^[3] ; Tambourgi, Elias Basile ^[4] ; Jozala, Angela Faustino ^[5] ; Barbosa Souto, Eliana Maria ^{[6, 7]} ; Mazzola, Priscila Gava ^[2]

Affiliation

^[1] Univ Campinas UNICAMP, Inst Biol, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Fac Pharmaceut Sci, Candido Portinari St, 200, Cidade Univ, BR-13083871 Campinas, SP - Brazil

^[3] Fed Univ Uberlandia UFU, Genet & Biochem Inst, Uberlandia, MG - Brazil

^[4] Univ Campinas UNICAMP, Sch Chem Engn, Campinas, SP - Brazil

^[5] Univ Sorocaba UNISO, LAMINFE Lab Ind Microbiol & Fermentat Proc, Sorocaba - Brazil

^[6] Univ Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra - Portugal

^[7] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga - Portugal

• Document type: Review article
• Source: Journal of Materials Science; v. 54, n. 16, p. 10963-10983, AUG 2019.
• Web of Science Citations: 2

Abstract

Hydrogels are polymeric networks with tridimensional structure, which are able to load water and other substances. Such property makes hydrogels suitable for innumerous applications in biomedical field. Hydrogels are being used as raw materials in pharmaceutical formulations for more than 60years, while significant progress is very well documented in topical use. Natural and synthetic polymers have been applied to develop smart hydrogels that respond to physiological stimuli to follow the release of the loaded bioactive ingredient. This paper discusses the most relevant polymers commonly used in pharmaceutical formulations for modified topical delivery. (AU)

• FAPESP's process: 16/03444-5 - Development of healing pharmaceutical formulation containing bromelain extracted from industrial wastes
• Grantee: Priscila Gava Mazzola
• Support Opportunities: Regular Research Grants